Information about Parkinson's Disease

Unknown Causes of Parkinson's Disease

Cause of Parkinson's disease, what do we know this? We do not know the cause of Parkinson's disease. Better understand the changes in the brain of Parkinson's disease situation. The same as in Alzheimer's disease. There was an analogy I did, "Crime location durumdayız well understood, but not yet absorbed the guilty are yet to find the trigger." Especially in the last 8-10 years, the developments in the genetics of Parkinson's disease, these cells die why we think we understand better. For example, "familial Parkinson's disease," this or that cause genetic mutations in all of the construction and destruction of proteins within cells that are associated with mutations of the genes. A protein encoded by one of these genes in Lewy cisimciğinin accumulating. Mutations in other genes in disease-causing proteins in the transformation of cells, genes involved in the collapse-making. Today at the point in the brain cells of Parkinson's patients have a problem I think in the old abolition of proteins. Proteins are constantly required the demolition of burned, and the roles of cell function and structure of the molecules in the cell. Yıprandıkları collapsed again when I need has been undertaken. If you are in any way in the cell, proteins that breaks the old system, if a problem, these obsolete proteins slowly begin to accumulate within the cell. These proteins are accumulated in a while, then they start to disrupt the normal functioning of the cell. Now you can not see the function of healthy, do not generate the necessary energy in the cell decides to commit suicide, and suicide genes are already available to run the genetic program closes its ignition. Assumption that the disease occurrence in the present.

This "contact closure" does not in some of the incident is why some people?

Current opinion, it emerges as a kind of genetic-environmental interaction. Some people from birth, some predisposition genes have brought. If the circuit enters in some environmental factors, susceptible to disease in humans is emerging. In other words, the majority of patients are not the only culprit of genetic, environmental factors are not the only culprit, the problem is a gene-environment interaction. Wrong genes in human disease risk rises with the wrong circles.

Anamnez'e again to put the diagnosis (the patient's disease, a doctor to tell his story) to apply?

Yes. A clinical diagnosis of Parkinson's disease as the principle diagnosis. You see the patient, "moving, there is a general slowdown. Walking gradually slowed down, smaller steps in. My body leaned forward.'ve Been right on my arm where there is a tremor. He am having trouble using my hand," he said, such as when the symptoms of this disease şüpheleniyorsunuz immediately. Examination findings, diagnosis, and ultimately our patients koyduruyor gözlemlediklerimiz. Patients and their relatives will be a good history of the disease, coupled with a good observation and examination to diagnose the majority of patients zorlanmıyoruz. Do you have a face which brings a patient to really shake, Do not, how titriyorsa shaking, he possesses. The tremors are usually excitement, anger or even joy arises or is increased. We also try to heyecanlandırmaya the patient during examination. During the inspection, a hand hand in a patient with neurological examination gözlerken call all the way from head to toe We review the functioning of the nervous system. We do this in a systematic also. Before we start the head and eye movements, vision, the face can be moved, hearing, sensation of the face, tongue and pharynx movements, we'll evaluate the sound and speech. Arms and legs in a certain system to review it. On the one hand we look at movement, strength, coordination, reflexes, hand, we assess the ability of small jobs. Do you have a loss of sensation, is there such a melting muscle mass does, look. After the march, review our position. As a result of all these examinations and assessments, the patient is what determines the findings. Do you really have to slow down, for example, Do you have a change in walking, his face is frozen (as we call it in the face mask), his voice has changed (a bit of Parkinson's patients in a low voice, light tone, and sometimes repeating syllables speak) identifies them. The patient's relatives said the findings of the inspection and bring together and decide whether or not Parkinson's syndrome in a patient.

Probably lies in the question of what comes under this phase of Parkinson's sendromunıın, namely the differential diagnosis: This is a classic Is Parkinson's disease, or one of its counterparts?

At this stage, we look at the thing, additional evidence suggesting Is there a similar one, to find an answer to it. That is the main sign of Parkinson's syndrome, one that extends beyond 4, a deceleration or limitation of eye movements, balance disorder, patients with severely decreased blood pressure when he stood up to have additional evidence, assess it. At the same time help başvururuz diagnostic methods, for example, brain computed tomography (CT) or magnetic resonance (MR) imaging, such as with. However, we want to make a statement which could lead to Parkinson's to exclude other causes of the brain vascular obstructions, tumors, such as the expansion of the spaces within the brain. Furthermore, the direct contribution of CT or MR would not meet the classic Parkinson's disease. That put the diagnosis of Parkinson's disease is a brain MR'ına looking at the classic.

Drug-response rate: 90-95 percent

Do you have a contribution to diagnosis of the patient's response to the treatment of Parkinson's?

One of the important findings in the differential diagnosis for us, whether you did not respond well to the treatment of Parkinson's patients. Classical Parkinson's disease, hastalanıl 90-95 percent respond positively to this or that drug. Classic Parkinson's disease, Parkinson's syndrome, which causes a large extent the relatives do not respond to treatment. In response to therapy also directs us to his diagnosis.