Reasons for the emergence of Parkinson's disease, Parkinson's Reasons
Disease, Parkinson's disease, dementia, and mental dysfunction reveals a unique but very relevant in this age. James Parkinson's disease, almost all young people. These symptoms, or they had an eye for him çarpmıyordu yet. But the last twenty years, we realized that more and more well-off act out the symptoms of Parkinson's disease symptoms related to the movement there are signs of what we call a number. For example, if the precision is applied to mental tests, as a group of Parkinson's disease patients, matched for age and education show a worse performance than the normals kıyaslandıklarında. Which areas of the wicked people? Attentional, concentration, executive functions and to plan call öngörebilme ability. Word fluency than the weaker. Parkinson's patients, including young ones, inward directed attention, in part, we call attention to export oriented functions are affected in particular.
Elderly patients, especially in the 70-80 years of age, the majority of Parkinson's disease and mental deterioration occurring over time is developing a form of dementia. In the last five-six years, I also worked on a particular topic. Two years ago, an international trial of a drug that provides improvement in the treatment of these patients also describe a certain extent. Parkinson's disease, dementia, a unique dementia, Alzheimer's disease are different, and therefore show different symptoms. Alzheimer's disease and memory disorders Front plandayken, Parkinson'lularda attention impairment, concentration impairment, executive dysfunction in the foreground. In addition, these patients often dreams, delusions, frequent daytime sleepiness, are symptoms such as night sleep, talk and act. Depression in Parkinson's disease is more common than dementia.
Depression is accompanied by
How often this is seen in patients with depression my teacher?
During the course of the disease, depression emerges in one of every two patients. Human he might think: "These persistent, slowly progressive, over the years with a chronic disease caused by the loss of certain functional. Thus, the depression is natural." But because it is so simple it seems that the change in depression. Because Parkinson's disease, such as for example, joint arthritis, chronic involvement and the loss of function, compared to other diseases, seems to be a higher rate of depression in Parkinson's patients. Based on this observation that depression is at least partly caused by the disease due to loss of brain cell believe that. For example, the classic depression in patients with decreased levels of the brain thought to substances such as serotonin and noradrenaline in patients with low-level depression has developed Parkinson's.
The third group concerns the mind and the mind as a symptom of Parkinson's disease psychosis is possible to speak of. Psychosis with illusions, hallucinations and delusions are referring to. These are usually at the beginning of the disease does not occur. I! e mean by delusions, false beliefs. For instance, "My wife is cheating on me, stealing my money, my children wants to get rid of me like" thoughts. I mean a different perception of the illusion of an existing alert. For example, a hat hanging askılıkta, but the patient, sees him as a head. There are in fact an object, there is a visual warning, but the patient perceives it different. Hallucinations (dream), the no non-detection of a stimulus, for example, are no items in common, but the patient "a man sitting on the couch" when there is no sound is heard, or "knock on the door, the phone rang, someone said," such as the perceived non-sensory warnings. Sometimes it is a common disorder in the other sensing "the presence of a body" feeling. The patient says, "It feels like there is one room, as if someone is standing behind me, as I look, there is not anybody."
All this is very rarely seen the first years of the patient. Approximately 70 percent of patients with dementia-type symptoms that are emerging. In some patients, drugs are seen as a side effect. In fact, the majority of drugs available for treatment of Parkinson's disease, especially in high doses can cause dreams
Parkinson's Alzheimer's
Alzheimer'dan more promising
Parkinson's disease in the brain exactly what's going on? The most characteristic feature of Parkinson's disease, our "brain stem" region that we call the two-sided, symmetrical settled as "black core" (substantia nigra) is considered as the formation of a cell group, degeneration and cell loss. Black core, within the small number, the cell contains around 800 thousand. For the emergence of the symptoms of Parkinson's disease, these cells have lost at least 60 percent-70. This means that in fact the disease, begins long before symptoms occur. With special imaging techniques to show the loss of these cells is also possible. This is a slowly progressive loss of cells. Reserve system, but all of the cells to be more than a backup 60'mı percent, after losing 70 percent of the symptoms are beginning to emerge. There are people in their lifetime so it did not show any symptom of Parkinson's, had died for no other reason. When examining the brains of cell loss was seen that there is 50 percent black and the nucleus. In other words, half lost in all the cells, whereas no signs of undisclosed. Besides the loss of this cell is a kind of black core protein in the cells see a ball of accumulated. However we "Lewy Apparatus" call. Discovered took the name of the German pathologist. This is very characteristic for Parkinson's disease, a finding essential. This cell loss in Parkinson's disease, the emergence of movement disorders related cause. Black kernel cells produce a chemical called dopamine. Dopamine, the neurotransmitter that we call our group, one of the substances used to provide communication among brain cells. A cell, to give a message to someone else at any time, one of these substances secreted, go to the second cell in the chemical sensors of its own previous warning and the first cell to cell, is the second outgoing message. Here we call these substances norotransmitter'ler or neurochemicals. Dopamine is one of them and the movement of a substance required for initiation and be in harmony. Dopamine, found in the black core is made of cells and their extensions through the basal ganglion'lar we say, deep in the brain, large cell groups located on both sides is being transmitted. After this has taken place, we start our movement so we can make a smooth and harmonious. This matter is the lack of dopamine in the cells died.
So does the lack of dopamine in this disease?
Yes, most of the major symptoms of Parkinson's disease related movement responsible for the lack of dopamine. Patients, a lack of dopamine, the more movement is so much about the problems. In particular, slow movement, muscle stiffness directly related to the amount of dopamine.
Between the severity of shivering with the black kernel of the direct reduction of dopamine, a proportion do not have one to one.
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