To reveal the disease model of alcoholism, genetic shift was first recognized. Genetic transition, the family being prone to alcoholism because of genetic features of German accents. The genetic features of the biological family structure provides a basis for the development of alcoholism in some people.
Before putting out the disease model, the biological predisposition to alcoholism, genetics of other diseases depending on the occurrence of the transition was detected açıklanmaktaydı better. For example, bipolar disorder, a genetic disease that is the best known passage, often found along with alcoholism. Therefore, the transition of alcoholism is not genetic, but cases of alcoholism associated with bipolar bozulduğuyla created such an impression can be suggested. Later studies, taking into account this point, one of the alcoholic mother or father of the children, the risk of developing alcoholism, regardless of all other psychiatric disorders in the community 3-4 times more than average risk has been demonstrated. Family studies, is not sufficient to determine the genetic transition. Raised in an alcoholic family, alcoholism are taken into consideration, it is possible to be transferred to the child factors, due to be grown.
Twin studies demonstrate the importance of genetics in terms of the transition is more convenient. Twin studies of alcoholism seen more than two brothers elegance of identical twins, fraternal twins are made by comparing this frequency. The incidence of alcoholism in identical twins with a single, more than double by twins. This finding reveals the importance of the genetic material. Identical twins are exactly the same genetic structure. Double any two siblings is genetically identical twins resemble each other up. As the incidence of alcoholism is increasing with the similarity of genetic structure.
The third group, demonstrating the transition of genetic research studies in adopted children. This is revealed by studies in general: an alcoholic biological parents of children with other families to leave the family in the first six months of next verilenlerinde incidence of alcoholism, however, adopted the same situation, but higher than the biological family is that children are not an alcoholic. In both cases, the adoptive mother or father in the family is not an alcoholic. Biological least one parent is an alcoholic, but non-alcoholic adoptive family, children at risk of developing alcoholism, alcoholic, non-biological family, adoptive family, but according to the situations developing in the mother or father is more than alcoholism. Adopted children, and genetic studies revealed the importance of the transition, as also stressed that it is more specific, based on factors related yetiştirilmeyle.
The existence of a biological predisposition to the aforementioned studies suggest that the transition with genetic predisposition to explain it so clearly identified in the original biological findings, studies conducted in this direction has revealed some of the features thought to be prepared predisposition to alcoholism.
To be resistant to the effect of alcohol, a feature that increases the risk of developing alcoholism. Etkilendiğiyle intoxicating effect of alcohol is about how brain cells from alcohol. At the same doses of alcohol, according to individuals at different levels leads to drunkenness. Mother or the fathers of the individuals identified in studies of alcoholism were found to be more resistant to the effect of their alcohol. Hence, the effect of alcohol being resistant to biological predisposition to alcoholism can be said to be an indicator. The amount of alcohol they consume less alcohol than the susceptible individuals to be more careful about alcohol consumption by individuals acting as resistance.
Another biological feature, the brain's electrical function is an indicator of changes in P 300 wave detected. P 300 wave, a stimulus is given (usually flashing lights) 300 milliseconds after a wave of electrical determined. In general, symbolized by the recognition of stimuli is assumed. However, studies in children of alcoholics P 300 wave was found to occur much later than normal.
Detectable differences in cognitive abilities in some special tests for alcoholism seems to be decisive. Detectable changes in alcoholics, especially the front region of the brain called the frontal lobe functions related changes. These findings of brain computed tomography and magnetic resonance imaging techniques are consistent with the changes detected.
The destruction of alcohol in the body that performs the final stage of the aldehyde dehydrogenase enzyme activity varies between individuals. Aldehyde dehydrogenase (ALDH) activity in individuals with low alcohol intake after the effects of alcohol no longer be described as a "hangover" state are exposed to more. From this table, the body responsible for the accumulated acetaldehyde. Acetaldehyde, an intermediate is a product of alcohol metabolism by ALDH is fragmented. Ethnic groups, as determined by genetic activity in the transition ALDH'ın vary. ALDH activity was lower than might be said that Asian races. Low ALDH activity has been suggested they were found in individuals less than alcoholism.
Chemical substances in the brain which is responsible for the message about the breakup of the mono-amine oxidase (MAO), the enzyme has an important role in explaining the formation of many psychiatric illnesses. MAO activity was found to be low in alcoholics. Normal rotates cessation of alcohol in the later periods is driven forward.
These findings set out in the existence of family studies to explore the biological predisposition I took out what works. Most of the children of alcoholics with repeated alkoliklerle. No definite tendency to be expressed based on the number of levels, even though they are obliged to herald biological properties. On the other hand supporting the idea that alcoholism is a disease in itself, the root of alcoholism on the moral values of the initiative for the elimination of prejudices olmaktadırlar.
Detectable differences in their biological properties in a single biological process makes it difficult to disclosure. For example, P 300 wave of work on the central nervous system show the effectiveness of ilgiyken ALDH enzyme in the liver. In this case, a predisposition to alcoholism put forward by many factors suggest that the overall result.
Genetic predisposition to the transition and the biological structure not determine completely the middle (along with other types of identical twins is between 55-60%, whereas alcoholism should be a 100% detection rate). Environmental factors, biological factors also participating in the determination of predisposition to alcoholism is to be effective. Environmental factors that interact directly affect the biological structure of biological systems (nutrition, injury, illness, etc..) Participate in determining the outcome, such as cognitive and psychological structures (education, first childhood years, cultural facilities, etc..) Participate in the system via.
Alcoholic who still would not pre-kestirebilecek case. Very, very, close relatives of those found in the alcoholic "hand out" diyebiliyoruz. The reason for yapamamamızın more information than currently inadequate, the predisposition to alcoholism alcoholism who participated in the event together, but independently of each other is determined by several factors. Factors at the same time the event is not in order to participate kestirebilmemizi what the outcome would be unsatisfactory and formulas.
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