Gammaglobulin today, is widely used for prophylaxis and treatment. Gammaglobulin certain cases, a few days after the application itself will provide a vaccine that can prevent active immunity.
Live attenuated virus vaccines (measles, rubella, mumps, Trimovax) for the development of immunity after the use of generally proliferation of viruses in the body is required. Gammaglobulin given, stop the proliferation of viruses. Therefore, to achieve a satisfactory immunization, Gammaglobulin at least 6 weeks after prophylaxis, the vaccine should be done preferably after waiting for 3 months. The pre-çaiışmalar, the use of oral immunoglobulin poliomiyelit or yellow fever vaccines have any negative interaction between the show.
If you use Gammaglobulin live shorter than 2 weeks elapsed between vaccination, the vaccine should be repeated after 3 months; intervening period is longer than 2 weeks, do not require it.
In case of contact with the disease live vaccine, Gammaglobulin can be used together. However, post-vaccination serologic testing seroconversion, the presence of serum antibodies vaccine provided immunity, this will destroy the effect of immunoglobulin and vaccination should not be forgotten, must be repeated after 3 months.
Gammaglobulin In contrast, killed vaccines are used by microorganisms (DTP, DTP polio, tetanus, rabies, hepatitis B, etc.) negatively affect the subsequent immune response. Nevertheless, some researchers believe that such an application from the low quality of immunity.
Gammaglobulin use of the serum antibody levels observed did not make any changes and is a valuable indicator of intercurrent infections, stress should also affect the serological tests.
Immune deficiency can be a child with a vaccine?
Typically, this condition can not respond to vaccination of children and thought to be conducive to the development of strong or abnormal reactions to the vaccine. This idea results in vaccination, whereas this is not an appropriate behavior.
Until recently identified as the clinical features of immune deficiencies. However, a better understanding of immunological events and advances in molecular biology, immune deficiencies recognized in many categories to separate (C. Griscelli):
1. Lack of antibody production:
2. Dissociated humoral immune failure: high levels of IgM, IgA and IgG failure, isolated from a lack of serum IgM; lgG2 and lgG4 isotype: Gammaglobulin infantile.
3. Predominantly affecting the failure of cellular immunity: DiGeorge syndrome, purine nucleotide phosphorylase deficiency.