NAYK, g our reputation, especially in western society, the most common causes of chronic liver diseases are among the. NAYK our country, the most common cause of chronic liver disease after viral hepatitis. NAYK simple steatosis, steatohepatitis, cirrhosis, and hepatocellular cancer, is a clinical broad spectrum.
I was variable depending on the methods used in diagnosis NAYK prevalence of society is seen in 24% of the 10-. With obesity levels are approximately 58-74% of this rate. Approximately 2.6% prevalence in children, 23-is 53% of obese children.
NAYK, part of the standard family practice, gastroenterology, endocrinology, cardiology, radiology, and gynecology as a metabolic disease in many areas of interest. NAYK, is clinically associated with many comorbidities. Of these morbidities of obesity, type 2 DM, HL best to be recognized. Studies, 30-to 100% in patients with NAYK obesity, type 2 diabetes by up to 75% 10-and 20-to 92% is defined as the frequency of HL.
G NAYK pathogenesis still remains unclear up to our reputation. The most widely accepted theory, multiple-beat (multi-hit), the hypothesis. The first beat, increased peripheral insulin resistance (IR) as a result of liver free fatty acids from adipose tissue as the latter depends on developing fatty liver disease has increased. The second beat as a result of the fat from the liver cells become susceptible to damage, oxidative stress, lipid peroxidation, and by the effect of inflammatory cytokines, inflammation (steatohepatitis). As the last beats, stellate cell activation by inflammatory mediators as a result of fibrosis developed. Some patients with simple steatosis, only some of them explained the reason for the development of steatohepatitis.
NAYK I usually asymptomatic patients. Some of the weakness, a feeling of fullness in the upper right quadrant of the abdominal symptoms may occur-such as pain. The presence of hepatomegaly, and one of the important findings on physical examination. NAYK asymptomatic patients, routine screening, the biochemical investigations and / or detected as incidental radiologic viewport.
Or Non-Alcoholic Liver Disease Diagnostic Laboratory GLI
NAYK heat clinical diagnosis, biochemical and histological evaluations are placed. Mild and moderate serum aminotransferase (alanine aminotransferase: ALT, aspartate aminotransferase: AST) elevation, and often one of the most common in patients with NAYK disorder in the laboratory. AST / ALT ratio is often less than 1, but this rate may vary in patients with advanced fibrosis. Serum gamma-glutamyl transferase (GGT) and alkaline fostafataz (ALP) levels may be higher in some patients. NAYK comorbid patients have a clinical presentation is related to these, for example, HL, laboratory abnormalities such as hyperglycemia, can also be detected. Hypoalbuminemia in patients with advanced fibrosis, thrombocytopenia, prothrombin time (PTZ) is prolonged. Patients with mild to moderate elevation of serum ferritin level is an important part of the determined and often interpreted as a marker for inflammation. NAYK serum autoantibody positivity can be seen. Approximately 33% of the low titer (<1:160) antinuclear antibody (ANA) positive, low titer (<1:40) antimitokondriyal antibody (AMA) positivity can be detected.
Lung damage in terms of biochemical liver tests (AST, ALT) elevation is an important finding in the diagnosis. However, these values are normally detected in approximately 40% of patients. Chronic (6 months duration) elevation of liver damage in those tests, causing damage to other causes (viral causes: hepatitis B, C, otoimm reputation reasons, alcohol-induced elevation of the metabolic causes: such as hemochromatosis) to rule out an absolute, NAYK important in the diagnosis.