What is colchicine

Colchicine, which inhibits neutrophil recruitment to interfere with microtubule formation a plant. Cutaneous and articular involvement is effective for control. Usually 1-2 mg / day dose is well tolerated


The most common side effects, gastrointestinal side effects (nausea, vomiting, diarrhea, abdominal pain). May cause alopecia and bone marrow suppression.


Alkylating Agents


Alkylating agents, DNA replication and acts. Are detrimental to the functions of lymphocytes and proliferative. CNS involvement in the treatment of refractory eye disease and in combination with corticosteroids are used. However, due to dose-dependent side effects that are resistant to other treatments should be applied in cases


Short-term chlorambucil therapy is applied in cases of refractory in BiH, the cases of 2 / 3 ocular involvement and improved and shown to reduce the number of attacks. Side effects are bone marrow suppression, hepatotoxicity, secondary malignancies and infertility. In the presence of neurological or cardiovascular involvement today recommended the use of an agent.


Methotrexate


Methotrexate, a folate analogue. Severe mucocutaneous involvement and helpful FAQ. Recommended the use of anterior uveitis cases.


Calcineurin Inhibitors


Calcineurin inhibitors, and the cycle affects the activation of T lymphocytes. A, although the most commonly used drugs in this group in particular is effective in refractory cases of eye disease. Are used in combination with corticosteroids, can be stabilized to lower the dose of corticosteroids. Neurotoxicity, hepatotoxicity, nephrotoxicity, hypertension, hirsutism, paresthesias, gastrointestinal manifestations, and there are side effects such as gingival hyperplasia.