Talked about two very important social disease. Which of the more successful in terms of treatment today?
More successful in the treatment of Parkinson's now. Today, almost all drugs used in Parkinson's patients, visible, able to provide a significant improvement in the same extent in patients with Alzheimer's, unfortunately, we do not see an improvement.
So what to do to prevent these diseases?
The whole world is looking for ways of prevention from diseases of the brain aging emerged. General tendency in humans to be a vitamin or nutrient contribution of any of them wish geçebilme front. In other words, people are seeking a solution to their dışlarında. "I have nothing to change the way I life, feeding, not I be forced to pay attention to myself, I take a vitamin pill or another, and these diseases korunayım" search inside. But so far no vitamin or other diseases may prevent this type of a substance alone did not show. We do not have such a magic pill. But we know there are risk factors. When you turn these risk factors for both diseases, the likelihood of diseases or azaltıyorsunuz. Among known risk factors for Alzheimer's disease, high blood pressure, cholesterol, saturated fat-rich diets have said that. If you get all this under control, keep your mind active and your body on a regular basis, you reduce the risk of the emergence of neuro-degenerative diseases.
In addition, the vitamins really do not have any effect?
Proven so far, the following doses of vitamins are taken up to now, Alzheimer's or Parkinson's disease, a finding that does not occur. High doses of vitamin E (2,000 mg a day) and treatment of Alzheimer's and Parkinson's disease, or whether the rate of progression of the disease, and such an effect was not investigated yavaşlatmadığı yavaşlatıp. In the context of prevention of this disease every day in all observational studies is brought into a degenerative disease of the brain that received 400 mg of vitamin E concluded that the risk is slightly reduced, but it should by as yet proven.
That is a proven impact on a regular basis do not have to take extra vitamins?
None. In addition to the daily food show any protective effect of vitamin 's so hard. Imagine that you have a thousand people, using the group to get these vitamins, vitamins are not a thousand people to compare, consider that you have received. Other properties of these two groups to reach a definite conclusion even need to keep for years. Is it possible to do so? In other words, these two groups over the years, roughly the same amount to provide the same things to eat, to live in the same way to provide the only difference between them to receive or not to take vitamins to ensure that possible? The only way to answering precisely the effect of vitamin additives, a method which is practically very difficult. Therefore, research so far has been (which is based on the method of estimating the amount of people's daily vitamin), the results show significant differences, for example, a study of vitamin E is protective finding someone else does not find any protective effect.
Top us
Top that with us?
Yes, it is the ball itself largely of people. We can get from the outside, preventing brain disorders do not have a magic pill yet. Load one's own shoulders, the ball in your foot, do something for yourself, in your hands. If you drive a healthy lifestyle, diet, mind-flood-physical activity if you notice, high blood pressure, diabetes, high cholesterol, such as if the risks and if you fight them effectively, reduce the risk of brain disease.
Brain aging and Alzheimer's and Parkinson's diseases, especially in trying to cope with the whole world is one of the social health problems. Turkish people would like to thank you for this matter lit. I have the book in our patients, their relatives and all our people wish to be useful.
Showing posts with label Alzheimer's Disease and Parkinson's. Show all posts
Showing posts with label Alzheimer's Disease and Parkinson's. Show all posts
Treatment of Parkinson's disease, and Battery Installation
Think of it as a kind of electrical vibration excitation. These cells normally have a certain rhythm of work. Very high frequency uyardığınızda out that the rhythm and function kalıyorlar tutturamıyorlar. Battery advantage of surgery is this: if the adverse effect occurs in the brain tissue is damaged the battery to change the settings, turn off or completely remove the battery as possible. Ie a method which can be recycled.
Technically the application is as follows: For each patient, the target coordinates of the center is estimated that the patient's brain. The patient's head using a special frame fixed firm in this framework is applied and the patient awake, the target coordinates are calculated in the region that we call a thin wire electrode is reached. We want to end this electrode can give warnings of violence and periods of electricity. The electrode is fixed to the skull and brought under the same skin as well as heart cells connected to a battery placed just under the skin of the chest. This is the battery on or off via remote control from outside, to control possible. How often, how severe and how much to do outside the setting of three different periods of time as possible to send a warning. Battery surgery, surgery advantageous than incineration, but much more expensive.
Both methods are applied in Turkey, I guess ...
Turkey, Istanbul, Ankara, Izmir and certain centers in major cities such as both methods are applied. Friend, a small number of neurosurgeons have specialized in this regard. Cases can be very effective when done right and in a way that best applies. Patients with particular method of putting a large extent düzelebiliyorlar battery, opening-closing, involuntary movements are lost, the dosage be reduced to half the side.
Parkinson's and exercise
Parkinson's disease, as well as medical treatment is said to be important in physical activity and exercise ...
Yes, especially physical activity and exercise have positive effects on muscle stiffness and slowness of movement. Unused muscles atrophy over time can be affected, ie, the masses go up or down in length may be shortened, if the stiff joints ettirilmedikleri regular exercise may lose the ability to move. Therefore, regular physical activity and exercise, to continue providing the functionality of the muscles and joints. For this purpose, all the joints and muscles of our patients, albeit for short periods each day çalıştırmalılar. This long-duration exercise, or do not have to be patient with severe yoracak. For example, walking is a very simple but effective form of exercise. One other option is swimming, is an extremely useful exercise in patients capable of shape. The patient previously yapageldiği tennis, football, sports activities such as maintenance of them also recommend if you have. Because this type of request carried out by the conscious motor movements, automatic movements such as walking less affected compared to the Parkinson's disease. By the way here where I say, automatically start thinking of walking in Parkinson's disease and maintaining a large extent problem-is presented, ie, "auto-pilot" was damaged, "voluntary, automatic pilot," is better. Therefore, patients given a command or a line in front of them to collect their attention, atladıklarında to walk over the threshold easier to initiate the step-by-distance grows.
Is there a particular proposed movement?
No, no, this can vary from patient to patient on a regular basis, however, all the major joints and muscles move them playing important. Not be neglected in terms of bed this morning kalkındığında movements can be done on a regular basis. Forward curved multi-drug therapy did not get benefit of this exercise, posture, balance disorder, or symptoms such as difficulty of verification might help the chair.
Technically the application is as follows: For each patient, the target coordinates of the center is estimated that the patient's brain. The patient's head using a special frame fixed firm in this framework is applied and the patient awake, the target coordinates are calculated in the region that we call a thin wire electrode is reached. We want to end this electrode can give warnings of violence and periods of electricity. The electrode is fixed to the skull and brought under the same skin as well as heart cells connected to a battery placed just under the skin of the chest. This is the battery on or off via remote control from outside, to control possible. How often, how severe and how much to do outside the setting of three different periods of time as possible to send a warning. Battery surgery, surgery advantageous than incineration, but much more expensive.
Both methods are applied in Turkey, I guess ...
Turkey, Istanbul, Ankara, Izmir and certain centers in major cities such as both methods are applied. Friend, a small number of neurosurgeons have specialized in this regard. Cases can be very effective when done right and in a way that best applies. Patients with particular method of putting a large extent düzelebiliyorlar battery, opening-closing, involuntary movements are lost, the dosage be reduced to half the side.
Parkinson's and exercise
Parkinson's disease, as well as medical treatment is said to be important in physical activity and exercise ...
Yes, especially physical activity and exercise have positive effects on muscle stiffness and slowness of movement. Unused muscles atrophy over time can be affected, ie, the masses go up or down in length may be shortened, if the stiff joints ettirilmedikleri regular exercise may lose the ability to move. Therefore, regular physical activity and exercise, to continue providing the functionality of the muscles and joints. For this purpose, all the joints and muscles of our patients, albeit for short periods each day çalıştırmalılar. This long-duration exercise, or do not have to be patient with severe yoracak. For example, walking is a very simple but effective form of exercise. One other option is swimming, is an extremely useful exercise in patients capable of shape. The patient previously yapageldiği tennis, football, sports activities such as maintenance of them also recommend if you have. Because this type of request carried out by the conscious motor movements, automatic movements such as walking less affected compared to the Parkinson's disease. By the way here where I say, automatically start thinking of walking in Parkinson's disease and maintaining a large extent problem-is presented, ie, "auto-pilot" was damaged, "voluntary, automatic pilot," is better. Therefore, patients given a command or a line in front of them to collect their attention, atladıklarında to walk over the threshold easier to initiate the step-by-distance grows.
Is there a particular proposed movement?
No, no, this can vary from patient to patient on a regular basis, however, all the major joints and muscles move them playing important. Not be neglected in terms of bed this morning kalkındığında movements can be done on a regular basis. Forward curved multi-drug therapy did not get benefit of this exercise, posture, balance disorder, or symptoms such as difficulty of verification might help the chair.
Parkinson's Treatment
Possible to distinguish roughly three in the treatment of Parkinson's disease: drug treatment, drug treatment and non-surgical treatment. First, start with general principles. The first step in treatment, to admit that it has a permanent brain disease. Will not exceed the disease is necessary to know and learn to live with it. Methods we have patients who survive for many years with a good quality of life possible. Some simple precautions and rules to be followed by their claims in the hands of their lives easier. Patients if they knew the characteristics of the disease, the life, activities, movements can shape according to him. For example, fatigue is a characteristic of Parkinson's disease and about half of Parkinsonluların complain of fatigue. If the patient knows this, configure a better day. We recommend that patients aşmamalarını fatigue limit. Home of women are a classic method. "All my work in the morning I do my strength, oturayım afternoon, and rest." But we do not recommend it. "Divide the Day. The morning, do the cooking, cleaning, do the afternoon, evening, or leave a little business" call. Yorulduklarını hissederlerse, to submit, and then re-initiate the search, as well as regular exercise, walking is recommended. This is a part of therapy for us. Would like to submit surely lose weight. Because the weight is already a normal person can create the problem. If the brain is ill, then more weight may become even more problematic. We recommend a healthy diet. Parkinson's disease do not have its own diet. Some medications taken with protein foods is absorbed more difficult, exceed the brain. Receiving the drugs for him, we recommend the consumption of protein foods, drugs and after a certain period. In addition, a healthy diet that apply to all people, also applies to Parkinson's ill. We want our patients to stay active both physically and mentally. Karşıyızdır completely withdraw into a corner. With modern methods of treatment of Parkinson's patients participate in daily life and business life are not an issue. Physiotherapy are also useful for patients who can not exercise on their own.
Dopamine and levodopa feature
Treatment of Parkinson's Disease Drug Treatment How is it done?
Alzheimer'da as drug treatment for this disease directly and non-specific forms of the disease have the original. Disease-specific treatment in the main strategy is to replace dopamine in the brain is no longer produced enough. Dopamine itself is not published. This is because the blood-brain dopamine aşamaması seddini. Normally, a barrier between blood and brain, there is a set of "blood-brain Great Wall" is defined as. Each substance in the blood to the brain can not. But they want to choose your own brain is. Dopamine is one of the substances can not pass to the brain. In this article we give the front of dopamine treatment. This substance called levodopa. Last levodopa to the brain, dopamine is converted and stored to be used by the brain cells that produce dopamine is started. We do not as a pure Levodopa'yı. Because we do so, out of brain cells in PD, dopamine is converted, for example, gastro-intestinal system. This is something we do not want that because it causes side effects. Levodopa'yı, converter converts dopamine (enzyme) together with a substance suppresses the offer, but this article does not pass to the brain, only the surrounding tissue remains.
Thus, we also levodopa, dopamine çevrilmiyor surrounding tissue and the majority goes to the brain. Rendered and are starting to be used after the brain dopamine. This drug is currently being considered as the most effective treatment of Parkinson's disease. Levodopa is a substance used since the early 1970s the end of 1960.
However, there is an observation as follows. For many years, patients treated with levodopa, some problems can occur, especially in young patients. For example, within five years after the initiation of treatment of patients with shorter duration of action of the drug in 50 percent of the 40-see. The patient says, "In the past when I bought ilacımı, no deterioration until the next dose hissetmezdim. But the second time in recent years, getting a dose of feel kötüleştiğimi approaching, increasing stiffness, slow to walk, starting to close." We call it the "motor (movement) fluctuations," or "cut-out periods' call. The patient in the context of the ability to act in a clear, going on an off. One of our dyskinesia or involuntary movements," we call a situation can occur. Sick of opening or closing is open to all entering the period of time or during the bending, bending, throwing, involuntary movements are emerging in the form of contraction. They are thought to be the following mechanism: At the beginning of brain dopamine levodopa'yı turning away from the blood, store and use at any time. But as time Scroll to the death of dopamine cells in the disease decreases with increasing storage capability. So if you have the brain at that moment in the blood how to take it and use of levodopa. so if you have the blood, using a lot away. In this case, the patient can walk, but can move as well as involuntary, the extra movements emerges. That these two complications, and off-off periods and on the modern treatment of levodopa-based drugs because of diskinezi'lerden delaying use in young patients. yeğliyoruz Instead, use other drugs before.
Now we understand better than ever, this does levodopa'nm complications, probably due to way we use our drug. Dopamine in the brain continuously salgılanıyor. However, we levodopa'yı outside a discontinuous way, from time to time offer, which interrupted the release of dopamine in the brain cause. The required warning is coming to the brain for a while, then disappear for a while. I mentioned these complications, we think he was born in the administration of intermittent levodopa'nın. For him, levodopa'yı more seamless, more constant question of whether we believe these issues do not currently being investigated. We have a drug that provides in part that, we are in an international study about him is still walking.
What this teacher work? When it began and when the result?
This is a more constant blood level of drug levodopa'nın kavuşup an additive that allows the brain to reach a more regular and continuous (entacapone) there. Levodopa'yı patients receiving conventional manner, the patients in this way kıyaslıyoruz. Approximately 800 patients in this study all over the world attending. The results will emerge within two years. If the brain levodopa'nın more continuous, less thought has occurred intermittently depending on the complications of this treatment be lowered to the timing of levodopa, the use of perspective will also change.
Our second group of drugs, the group defined as dopamine agonists. Binding to dopamine receptors in the brain creating its wider impact of these drugs, are a kind of mimic its effect. In this group there are different drugs (bromocriptine, pergolide, lizürid, cabergoline, pramipexole, ropinirol, pribedil) and all are in Turkey. We prefer to start them young age in patients, at birth need to add levodopa'yı treatment.
Do not have obtained any other weapons?
There are also another group of drugs. One of them antikoliner-jikler. Action of dopamine in the brain called the basal ganglion'laı carrier with the message of a chemical which has a balance between acetylcholine. Dopamine decreased when the amount of acetylcholine remains relatively high. Dopamine-acetylcholine balance by reducing the effect of Anticholinergics asetilkolin'in partly re-establishment offers. This group of young people and shake the forefront of the use in patients. Elderly patients do not prefer, because of memory impairment, confusion are able.
What is the latest in the Treatment of Parkinson's drugs?
These "enzyme inhibitors" is a group we call the two different flavors: "COMT enzyme inhibitors," and "MAO enzyme inhibitors." The first group of drugs to the brain by blocking the effect of the use of the adjacent tissues outside the brain levodopa'nın increase the amount of levodopa reaching the second group, the brain cells produce dopamine levodopa'dan reaching their own his or outside. in the brain by preventing the destruction of drugs to ensure a longer stay. The second group includes both alone and levodopa can be used with other drugs. COMT inhibitors, the drugs that contain only levodoa they work together because their purpose is to provide access to the brain is already more levodopa'nın.
Is there an alternative to giving the oral medication? Yes, there are methods of making any other kind of drugs. For example, thanks to a newly developed method of levodopa, inserted into the abdomen small, intestine duodenum through a cannula can be given continuously. Drug absorb when given directly into the intestine can be provided a continuity and regularity. However, in a way that is quite troublesome. Another one of agonistler'inden dopamine (apomorphine), a thin needle is inserted under the skin and programmable, so you can adjust the amount of drug given through a small pump continuously given to the body and to ensure continuity of the brain dopaminergic stimulation. This method is incapable of motion in patients living in the problem of fluctuation is quite works. Or the sudden closing of patients with the same drug on their own they can be applied in the form of single injections. Given such a short period of drug effect is 5 minutes, until the effect takes 1-2 hours to half. During that time also, for example, are external and off the patient gets the chance to go home. There is another emerging method. This is yet another dopamine agonist'inin (rotigotin) given once a day through the skin in the form of a tape pasted.
Also said that non-specific methods of treatment for the disease, what they are?
For example, depression medications. In these patients, depression often told rastladığımızı. The patient's age, other bodily diseases, and used other drugs by looking at whether we decide that we will choose which of depression medication. Or the patient's dreams, delusions have been using drugs used in schizophrenia. Mental disorders caused by Parkinson's disease and Par-kinson dementia group also started to use a new drug. Our clinic is a major international study coordinated with the use of Alzheimer's disease so far, "cholinesterase inhibitors" of a drug group (rivastigmine) have shown that Parkinson's disease caused by the bunamada useful.
There is talk also is useful in a pod, right?
Fresh broad beans, the above-mentioned eniğimiz significantly, dopamine precursor which contains leuodopa. There are approximately 135 milligrams per gram leıvdopa fresh pod 40-50, that is, drugs we give our substance naturally present in the pod. But the pod does not replace any form of drug treatment. Provided that a few hundred grams of fresh bean Yoğurtsuz day cut-out, especially in patients who can stay open longer. However much they beat the emergence of adverse effects, including involuntary movements especially in the cause.
Parkinson's surgery
Drug treatment told, it's time for surgery.
In fact, a very old history of surgical intervention is based, was first applied in the 1940s. Then, with the emergence of effective drugs removed from the rack. Surgical methods since the early 1990s started to become popular again, especially levodopa'nın involuntary movements caused by long-term use in patients with yarayabileceği after being presented with numerous jobs. Mechanism on the basis of surgery, there are: some of the centers of the brains of Parkinson's disease, dopamine deficiency as the more trying. Characteristics of these centers are more suppressive when they work, under their control and to act in the brain regions necessary to give the last orders baskılıyorlar. The aim of surgery in uncontrolled areas of Parkinson's less work than trying to make it. For this purpose, two different methods are applied. One of them is destructive (devastating), or "burn surgery," say, the second is the "deep brain stimulation" or "with electrode stimulation," or "Battery insertion surgery call. Uyutulmadan Both methods are applied to the patient.
Incineration is applied and how the success of surgery?
High-frequency radio waves in the region working with partially dağlanıyor more. This method, for example in patients with shake it just works. But it also has some limitations. First, this region of the brain damage and you want to give it more yaktıysanız damage can be permanent. Is going to want at least a temporary effect yaktıysanız. For example, patient 3 months, 6 months is going well, but then another problem arises again if the symptoms of burning double-sided yapılamaması. Let's say that on the one hand was trembling so, that way you implement for the incineration surgery. The risk of unilateral intervention is quite low, around 3-5 per cent. But this time the patient began to shake the other side. Also when you want to burn it there, rising to 30 percent of the risk of occurrence of complications and they are serious risks, speech impairment, balance impairment, degradation, such as swallowing. For her "devastating surgical" useful, but often a one-sided method is applied. Especially in patients with tremor and involuntary movements of works.
Parkinson's surgery is basically aimed at 3 different centers. Where intervention will be determined by the patient's complaint. The second method, the surgical intervention centers in the brain are similar. Here, the center of the target rather than burned electrodes, high-frequency stimulation of being held captive.
Dopamine and levodopa feature
Treatment of Parkinson's Disease Drug Treatment How is it done?
Alzheimer'da as drug treatment for this disease directly and non-specific forms of the disease have the original. Disease-specific treatment in the main strategy is to replace dopamine in the brain is no longer produced enough. Dopamine itself is not published. This is because the blood-brain dopamine aşamaması seddini. Normally, a barrier between blood and brain, there is a set of "blood-brain Great Wall" is defined as. Each substance in the blood to the brain can not. But they want to choose your own brain is. Dopamine is one of the substances can not pass to the brain. In this article we give the front of dopamine treatment. This substance called levodopa. Last levodopa to the brain, dopamine is converted and stored to be used by the brain cells that produce dopamine is started. We do not as a pure Levodopa'yı. Because we do so, out of brain cells in PD, dopamine is converted, for example, gastro-intestinal system. This is something we do not want that because it causes side effects. Levodopa'yı, converter converts dopamine (enzyme) together with a substance suppresses the offer, but this article does not pass to the brain, only the surrounding tissue remains.
Thus, we also levodopa, dopamine çevrilmiyor surrounding tissue and the majority goes to the brain. Rendered and are starting to be used after the brain dopamine. This drug is currently being considered as the most effective treatment of Parkinson's disease. Levodopa is a substance used since the early 1970s the end of 1960.
However, there is an observation as follows. For many years, patients treated with levodopa, some problems can occur, especially in young patients. For example, within five years after the initiation of treatment of patients with shorter duration of action of the drug in 50 percent of the 40-see. The patient says, "In the past when I bought ilacımı, no deterioration until the next dose hissetmezdim. But the second time in recent years, getting a dose of feel kötüleştiğimi approaching, increasing stiffness, slow to walk, starting to close." We call it the "motor (movement) fluctuations," or "cut-out periods' call. The patient in the context of the ability to act in a clear, going on an off. One of our dyskinesia or involuntary movements," we call a situation can occur. Sick of opening or closing is open to all entering the period of time or during the bending, bending, throwing, involuntary movements are emerging in the form of contraction. They are thought to be the following mechanism: At the beginning of brain dopamine levodopa'yı turning away from the blood, store and use at any time. But as time Scroll to the death of dopamine cells in the disease decreases with increasing storage capability. So if you have the brain at that moment in the blood how to take it and use of levodopa. so if you have the blood, using a lot away. In this case, the patient can walk, but can move as well as involuntary, the extra movements emerges. That these two complications, and off-off periods and on the modern treatment of levodopa-based drugs because of diskinezi'lerden delaying use in young patients. yeğliyoruz Instead, use other drugs before.
Now we understand better than ever, this does levodopa'nm complications, probably due to way we use our drug. Dopamine in the brain continuously salgılanıyor. However, we levodopa'yı outside a discontinuous way, from time to time offer, which interrupted the release of dopamine in the brain cause. The required warning is coming to the brain for a while, then disappear for a while. I mentioned these complications, we think he was born in the administration of intermittent levodopa'nın. For him, levodopa'yı more seamless, more constant question of whether we believe these issues do not currently being investigated. We have a drug that provides in part that, we are in an international study about him is still walking.
What this teacher work? When it began and when the result?
This is a more constant blood level of drug levodopa'nın kavuşup an additive that allows the brain to reach a more regular and continuous (entacapone) there. Levodopa'yı patients receiving conventional manner, the patients in this way kıyaslıyoruz. Approximately 800 patients in this study all over the world attending. The results will emerge within two years. If the brain levodopa'nın more continuous, less thought has occurred intermittently depending on the complications of this treatment be lowered to the timing of levodopa, the use of perspective will also change.
Our second group of drugs, the group defined as dopamine agonists. Binding to dopamine receptors in the brain creating its wider impact of these drugs, are a kind of mimic its effect. In this group there are different drugs (bromocriptine, pergolide, lizürid, cabergoline, pramipexole, ropinirol, pribedil) and all are in Turkey. We prefer to start them young age in patients, at birth need to add levodopa'yı treatment.
Do not have obtained any other weapons?
There are also another group of drugs. One of them antikoliner-jikler. Action of dopamine in the brain called the basal ganglion'laı carrier with the message of a chemical which has a balance between acetylcholine. Dopamine decreased when the amount of acetylcholine remains relatively high. Dopamine-acetylcholine balance by reducing the effect of Anticholinergics asetilkolin'in partly re-establishment offers. This group of young people and shake the forefront of the use in patients. Elderly patients do not prefer, because of memory impairment, confusion are able.
What is the latest in the Treatment of Parkinson's drugs?
These "enzyme inhibitors" is a group we call the two different flavors: "COMT enzyme inhibitors," and "MAO enzyme inhibitors." The first group of drugs to the brain by blocking the effect of the use of the adjacent tissues outside the brain levodopa'nın increase the amount of levodopa reaching the second group, the brain cells produce dopamine levodopa'dan reaching their own his or outside. in the brain by preventing the destruction of drugs to ensure a longer stay. The second group includes both alone and levodopa can be used with other drugs. COMT inhibitors, the drugs that contain only levodoa they work together because their purpose is to provide access to the brain is already more levodopa'nın.
Is there an alternative to giving the oral medication? Yes, there are methods of making any other kind of drugs. For example, thanks to a newly developed method of levodopa, inserted into the abdomen small, intestine duodenum through a cannula can be given continuously. Drug absorb when given directly into the intestine can be provided a continuity and regularity. However, in a way that is quite troublesome. Another one of agonistler'inden dopamine (apomorphine), a thin needle is inserted under the skin and programmable, so you can adjust the amount of drug given through a small pump continuously given to the body and to ensure continuity of the brain dopaminergic stimulation. This method is incapable of motion in patients living in the problem of fluctuation is quite works. Or the sudden closing of patients with the same drug on their own they can be applied in the form of single injections. Given such a short period of drug effect is 5 minutes, until the effect takes 1-2 hours to half. During that time also, for example, are external and off the patient gets the chance to go home. There is another emerging method. This is yet another dopamine agonist'inin (rotigotin) given once a day through the skin in the form of a tape pasted.
Also said that non-specific methods of treatment for the disease, what they are?
For example, depression medications. In these patients, depression often told rastladığımızı. The patient's age, other bodily diseases, and used other drugs by looking at whether we decide that we will choose which of depression medication. Or the patient's dreams, delusions have been using drugs used in schizophrenia. Mental disorders caused by Parkinson's disease and Par-kinson dementia group also started to use a new drug. Our clinic is a major international study coordinated with the use of Alzheimer's disease so far, "cholinesterase inhibitors" of a drug group (rivastigmine) have shown that Parkinson's disease caused by the bunamada useful.
There is talk also is useful in a pod, right?
Fresh broad beans, the above-mentioned eniğimiz significantly, dopamine precursor which contains leuodopa. There are approximately 135 milligrams per gram leıvdopa fresh pod 40-50, that is, drugs we give our substance naturally present in the pod. But the pod does not replace any form of drug treatment. Provided that a few hundred grams of fresh bean Yoğurtsuz day cut-out, especially in patients who can stay open longer. However much they beat the emergence of adverse effects, including involuntary movements especially in the cause.
Parkinson's surgery
Drug treatment told, it's time for surgery.
In fact, a very old history of surgical intervention is based, was first applied in the 1940s. Then, with the emergence of effective drugs removed from the rack. Surgical methods since the early 1990s started to become popular again, especially levodopa'nın involuntary movements caused by long-term use in patients with yarayabileceği after being presented with numerous jobs. Mechanism on the basis of surgery, there are: some of the centers of the brains of Parkinson's disease, dopamine deficiency as the more trying. Characteristics of these centers are more suppressive when they work, under their control and to act in the brain regions necessary to give the last orders baskılıyorlar. The aim of surgery in uncontrolled areas of Parkinson's less work than trying to make it. For this purpose, two different methods are applied. One of them is destructive (devastating), or "burn surgery," say, the second is the "deep brain stimulation" or "with electrode stimulation," or "Battery insertion surgery call. Uyutulmadan Both methods are applied to the patient.
Incineration is applied and how the success of surgery?
High-frequency radio waves in the region working with partially dağlanıyor more. This method, for example in patients with shake it just works. But it also has some limitations. First, this region of the brain damage and you want to give it more yaktıysanız damage can be permanent. Is going to want at least a temporary effect yaktıysanız. For example, patient 3 months, 6 months is going well, but then another problem arises again if the symptoms of burning double-sided yapılamaması. Let's say that on the one hand was trembling so, that way you implement for the incineration surgery. The risk of unilateral intervention is quite low, around 3-5 per cent. But this time the patient began to shake the other side. Also when you want to burn it there, rising to 30 percent of the risk of occurrence of complications and they are serious risks, speech impairment, balance impairment, degradation, such as swallowing. For her "devastating surgical" useful, but often a one-sided method is applied. Especially in patients with tremor and involuntary movements of works.
Parkinson's surgery is basically aimed at 3 different centers. Where intervention will be determined by the patient's complaint. The second method, the surgical intervention centers in the brain are similar. Here, the center of the target rather than burned electrodes, high-frequency stimulation of being held captive.
Parkinson's Disease Risk Factors
What is the number one risk factor for Parkinson's disease?
Also the number one risk factor for Parkinson's disease, age. Age also increases the frequency of occurrence of Parkinson's disease progresses.
In other words, as in prostate, as in dementia. People long lives, will inevitably increase the risks?
One of the less their long-living. Another risk factor, significant head trauma. We mean by significant head injury, severe enough to cause loss of consciousness due to head trauma. In men than women seem a little more. Odds, l'e 1.5 'tour. However, protective factors can also look at if there is, he has an interesting observation: less than Parkinson's disease is seen in smokers.
Do you think it affected our patients over the age of a given? So reluctantly, let's not encourage smoking.
I got impressed. Because the damage smoking has done so much else that ... However, some ingredients in cigarettes should be certain that provides a protective effect. For example, nicotine in the brain by stimulating certain areas may be providing protection. We do our job, to recommend to people, not non-drinking, cigarette smoking, which factor in providing this protection really, it is a harmless way to identify and work with that factor. I do not see any objection to convey to him this finding. This was shown many times in different studies. In fact, everyone initially thought comes to mind in the first place, smokers die earlier than the elderly, and Parkinson's disease also occurs in humans to be naturally in the form of such a result. Subsequently a study was performed in China. Take a few thousand people watched over the years, smokers and nonsmokers, and looked at the emergence of many new cases of Parkinson's disease in smokers is seen less approved. Even a "dose-response" relationship they found, even, that most smokers risk groups, at least. One other observation about the coffee. Also thought to be a specific protective effect of coffee. The importance of this work for us, the people, "Smoking or coffee for the" not in the context of mean. It is important to find which mechanisms are displaying this effect and use it to treat disease.
Rastlanılıyor Parkinson's disease, how often and at what age is seen more?
The increasing incidence of Parkinson's disease, a disease with age. The average age of onset between 55-60, but 5 percent of patients under the age of 40 starts. Frequency of about 1 percent are thought to be over the age of 60-65. This percentage, when applied to the structure of Turkey's population, we estimate, around 120 thousand in our country is in the form of Parkinson's disease.
The number of patients with Alzheimer's remember that about 250 thousand. This means that the number of Parkinsonluların remains at the level of half of Alzheimer's patients ... As I mentioned above 5 percent, however, the disease starts under the age of 40, they are not included in this account. We are in this group the "young-onset Parkinson's" call. Us, we call sporadic, ie non-familial, occurring at random each family rather than Parkinson's disease in older age emerges. Although age of onset of the disease is likely to be genetic falls is rising so much, most of the starters under the age of 30, under the age of 20 starters, almost all of the types of cases are familial genetic disorders. Parkinson's disease can occur in young age is important to know. Sometimes, "But in this patient 30 years old, is at this age does Parkinson's," he falls sick relatives in doubt. Parkinson's disease can begin even in very young age. The youngest patient we have seen, the symptoms started about a sick, aged 14-15. Consanguineous marriage, born a boy, and found that carries a known genetic mutation.
This means that the risk of consanguineous marriages is increasing.
Yes consanguineous marriage increases the risk of familial Parkinson's disease. On the other hand will not notice a difference between the races.
Is more common in rural areas
So what way of life, Do you have a climate impact?
There is an interesting observation about life as follows: Parkinson's disease, those living in rural areas, is seen more frequently than those living in the city. Well water is more common in users.
Why are you so what my teacher?
Drugs used in agriculture is thought to play a role. The reason of such thought in the early 1980s the United States lies. He emerged in a short time in California a few years, Parkinson's disease, there is a lot of young professionals, attracted the attention of neurology. The neurologist (Dr. William Langston) explores the common characteristics of the patients. One part of the chemistry faculty of reading, trying to understand the drug on their own.
MPPP are trying to do the drug name. Students in the basement of their house to set up a small laboraruvar, they want to manufacture the drug. Dr. Identifying ways that the location of the laboratory Langston amateur, go, they have made of the last remaining example of in vitro drug-taking, analysis is building. Viewing that this drug is not MPPP, MPTP has been. MPTP is a highly toxic substance.
This toxic substance, affected the brains of young people?
Yes, but only one area of their brains, the main region affected in Parkinson's disease in the black beans. Subsequent experiments in this article it is understood that, just touch the black kernel kills cells elsewhere. MPTP'nin, this feature is very selective toxic Dr. Langston'ın observation and the ability to pursue the matter through bırakmayıp track driving on Parkinson's disease has become a very important finding. Black core is a substance called black color of the cells within the nöromelanin. Only cells that contain melanin in neuro-taking into MPTP'yi and, therefore, MPTP only harms the cells. MPTP'nin later when you look at the structure of the chemical used in agriculture as a major structural similarity is clear and certain drugs. That argument may be more common in Parkinson's agricultural areas where drugs were used.
Truly an amazing story, Dr. What information received from Langston. I think anything positive sciences is not coincidental.
Yes, I agree, Pasteur Remember, "Luck helps, but grew up heads." Dr. Langston is now in California, "James Fox, Parkinson's Institute" of the director. Significant contribution to research in the field was discovered MPTP'yi and Parkinson's. Now this material is used in animal models, such as monkeys generated model of Parkinson's disease. You know, the first stages of drug research is done on animals. A similar picture emerges when MPTP monkeys in human Parkinson. Here are the new drugs are tested in animal models of this type of human research before moving. His understanding of the mechanism of cell death for both MPTP'nin, as well as the creation of a model in terms of laboratory animals has been a great contribution to us.
The role of genetics
Returning again to genetic disease ...
The direction of familial Alzheimer's disease, Parkinson's disease is the same under the hood as possible to examine two: First, familial predisposition. If you become ill first-degree relatives the risk of developing Parkinson sprung up to 2-3 times higher than those without a family is going. The second type of familial Parkinson's disease directly. Our knowledge in this area has increased rapidly in the last 8-10 years. To date, 10 of familial Parkinson's type is fully determined. Some of them, "çekkin genes" is a part of the "dominant genes" is made with. You know, people who carry two of every gene. Someone from the mother, the other one comes from the father. Çekkin genes last illness, if only one person has the defective gene there is no problem. When a gene is damaged two diseases occur together. This type of consanguineous marriage, çekkin genes carried by the emergence of more common diseases, because the relatives come to the same gene pool. If you have a family history of genetic disorders and the same family if he marries two people, two defective genes, the possibility of a combination of rising ...
If we question the dominant genes?
Some types of Parkinson's disease, caused by dominant genes. This type of genetic diseases carried by dominant genes in a single defective gene is sufficient for the emergence of the disease. 5 of 10 types of familial Parkinson's disease genes identified so far. Interestingly, almost all of these genes within a cell, the construction of some proteins, but rather the destruction of obsolete proteins.
How long will these developments happened?
In the last ten years. First, a large family of Italian origin, the first Parkinson's gene identified. It was a raid of this gene. Immediately after the first çekkin gene found in Japan. Then others began coming in rapidly.
Let us also mention a little familial or genetic features of Parkinson's disease?
Çekkin particular type of gene causes familial Parkinson's disease, can begin at an early age. In addition, some non-typical for Parkinson's disease patients show symptoms. The dominant genes to cause the different. Sometimes the same family, who carry the same gene, and stare, a part of the early starts, late starts in a part of. As a result, the disease began at a young age and also shows atypical features, then we suspect that genetic being. But other aspects of the genetic type of Parkinson's disease or atypical features show does not start at a young age. Genetic origin of some types of Parkinson's disease, called sporadic non-hereditary type göstermiyorlar no difference.
Both Alzheimer's, Parkinson's disease and there is a lot about the still unknown.
Mechanism of thousands of scientists working on. But how can it be absorbed he still could not find the trigger?
Relatives of the patients, and patients sometimes also ask this question. "How is it still does not cure it. Medicine, he proceeded to say" they say. But the remedy of these diseases have to say, especially to stop and turn back the mean cell death, more or less equivalent to solving the mystery of life. If you know how cell death and aging of the people in a sense, we find the way to stop him, we found a way to prevent or even die. Understand the mechanism of cell death and is responsible for it to decrypt the genetic code of life as almost solve. Supposed to do this, not that easy.
Çözseniz this disease instead of the other diseases will be considered absolutely. You know, a full fifteen-twenty years ago, the disease appeared to have never known.
Historically, when you look at this way, the War with nature is always new obstacles, we also strive to overcome them. Maybe as you say that we find solutions to these diseases other diseases, problems may occur. Then you begin to fight with them.
Also the number one risk factor for Parkinson's disease, age. Age also increases the frequency of occurrence of Parkinson's disease progresses.
In other words, as in prostate, as in dementia. People long lives, will inevitably increase the risks?
One of the less their long-living. Another risk factor, significant head trauma. We mean by significant head injury, severe enough to cause loss of consciousness due to head trauma. In men than women seem a little more. Odds, l'e 1.5 'tour. However, protective factors can also look at if there is, he has an interesting observation: less than Parkinson's disease is seen in smokers.
Do you think it affected our patients over the age of a given? So reluctantly, let's not encourage smoking.
I got impressed. Because the damage smoking has done so much else that ... However, some ingredients in cigarettes should be certain that provides a protective effect. For example, nicotine in the brain by stimulating certain areas may be providing protection. We do our job, to recommend to people, not non-drinking, cigarette smoking, which factor in providing this protection really, it is a harmless way to identify and work with that factor. I do not see any objection to convey to him this finding. This was shown many times in different studies. In fact, everyone initially thought comes to mind in the first place, smokers die earlier than the elderly, and Parkinson's disease also occurs in humans to be naturally in the form of such a result. Subsequently a study was performed in China. Take a few thousand people watched over the years, smokers and nonsmokers, and looked at the emergence of many new cases of Parkinson's disease in smokers is seen less approved. Even a "dose-response" relationship they found, even, that most smokers risk groups, at least. One other observation about the coffee. Also thought to be a specific protective effect of coffee. The importance of this work for us, the people, "Smoking or coffee for the" not in the context of mean. It is important to find which mechanisms are displaying this effect and use it to treat disease.
Rastlanılıyor Parkinson's disease, how often and at what age is seen more?
The increasing incidence of Parkinson's disease, a disease with age. The average age of onset between 55-60, but 5 percent of patients under the age of 40 starts. Frequency of about 1 percent are thought to be over the age of 60-65. This percentage, when applied to the structure of Turkey's population, we estimate, around 120 thousand in our country is in the form of Parkinson's disease.
The number of patients with Alzheimer's remember that about 250 thousand. This means that the number of Parkinsonluların remains at the level of half of Alzheimer's patients ... As I mentioned above 5 percent, however, the disease starts under the age of 40, they are not included in this account. We are in this group the "young-onset Parkinson's" call. Us, we call sporadic, ie non-familial, occurring at random each family rather than Parkinson's disease in older age emerges. Although age of onset of the disease is likely to be genetic falls is rising so much, most of the starters under the age of 30, under the age of 20 starters, almost all of the types of cases are familial genetic disorders. Parkinson's disease can occur in young age is important to know. Sometimes, "But in this patient 30 years old, is at this age does Parkinson's," he falls sick relatives in doubt. Parkinson's disease can begin even in very young age. The youngest patient we have seen, the symptoms started about a sick, aged 14-15. Consanguineous marriage, born a boy, and found that carries a known genetic mutation.
This means that the risk of consanguineous marriages is increasing.
Yes consanguineous marriage increases the risk of familial Parkinson's disease. On the other hand will not notice a difference between the races.
Is more common in rural areas
So what way of life, Do you have a climate impact?
There is an interesting observation about life as follows: Parkinson's disease, those living in rural areas, is seen more frequently than those living in the city. Well water is more common in users.
Why are you so what my teacher?
Drugs used in agriculture is thought to play a role. The reason of such thought in the early 1980s the United States lies. He emerged in a short time in California a few years, Parkinson's disease, there is a lot of young professionals, attracted the attention of neurology. The neurologist (Dr. William Langston) explores the common characteristics of the patients. One part of the chemistry faculty of reading, trying to understand the drug on their own.
MPPP are trying to do the drug name. Students in the basement of their house to set up a small laboraruvar, they want to manufacture the drug. Dr. Identifying ways that the location of the laboratory Langston amateur, go, they have made of the last remaining example of in vitro drug-taking, analysis is building. Viewing that this drug is not MPPP, MPTP has been. MPTP is a highly toxic substance.
This toxic substance, affected the brains of young people?
Yes, but only one area of their brains, the main region affected in Parkinson's disease in the black beans. Subsequent experiments in this article it is understood that, just touch the black kernel kills cells elsewhere. MPTP'nin, this feature is very selective toxic Dr. Langston'ın observation and the ability to pursue the matter through bırakmayıp track driving on Parkinson's disease has become a very important finding. Black core is a substance called black color of the cells within the nöromelanin. Only cells that contain melanin in neuro-taking into MPTP'yi and, therefore, MPTP only harms the cells. MPTP'nin later when you look at the structure of the chemical used in agriculture as a major structural similarity is clear and certain drugs. That argument may be more common in Parkinson's agricultural areas where drugs were used.
Truly an amazing story, Dr. What information received from Langston. I think anything positive sciences is not coincidental.
Yes, I agree, Pasteur Remember, "Luck helps, but grew up heads." Dr. Langston is now in California, "James Fox, Parkinson's Institute" of the director. Significant contribution to research in the field was discovered MPTP'yi and Parkinson's. Now this material is used in animal models, such as monkeys generated model of Parkinson's disease. You know, the first stages of drug research is done on animals. A similar picture emerges when MPTP monkeys in human Parkinson. Here are the new drugs are tested in animal models of this type of human research before moving. His understanding of the mechanism of cell death for both MPTP'nin, as well as the creation of a model in terms of laboratory animals has been a great contribution to us.
The role of genetics
Returning again to genetic disease ...
The direction of familial Alzheimer's disease, Parkinson's disease is the same under the hood as possible to examine two: First, familial predisposition. If you become ill first-degree relatives the risk of developing Parkinson sprung up to 2-3 times higher than those without a family is going. The second type of familial Parkinson's disease directly. Our knowledge in this area has increased rapidly in the last 8-10 years. To date, 10 of familial Parkinson's type is fully determined. Some of them, "çekkin genes" is a part of the "dominant genes" is made with. You know, people who carry two of every gene. Someone from the mother, the other one comes from the father. Çekkin genes last illness, if only one person has the defective gene there is no problem. When a gene is damaged two diseases occur together. This type of consanguineous marriage, çekkin genes carried by the emergence of more common diseases, because the relatives come to the same gene pool. If you have a family history of genetic disorders and the same family if he marries two people, two defective genes, the possibility of a combination of rising ...
If we question the dominant genes?
Some types of Parkinson's disease, caused by dominant genes. This type of genetic diseases carried by dominant genes in a single defective gene is sufficient for the emergence of the disease. 5 of 10 types of familial Parkinson's disease genes identified so far. Interestingly, almost all of these genes within a cell, the construction of some proteins, but rather the destruction of obsolete proteins.
How long will these developments happened?
In the last ten years. First, a large family of Italian origin, the first Parkinson's gene identified. It was a raid of this gene. Immediately after the first çekkin gene found in Japan. Then others began coming in rapidly.
Let us also mention a little familial or genetic features of Parkinson's disease?
Çekkin particular type of gene causes familial Parkinson's disease, can begin at an early age. In addition, some non-typical for Parkinson's disease patients show symptoms. The dominant genes to cause the different. Sometimes the same family, who carry the same gene, and stare, a part of the early starts, late starts in a part of. As a result, the disease began at a young age and also shows atypical features, then we suspect that genetic being. But other aspects of the genetic type of Parkinson's disease or atypical features show does not start at a young age. Genetic origin of some types of Parkinson's disease, called sporadic non-hereditary type göstermiyorlar no difference.
Both Alzheimer's, Parkinson's disease and there is a lot about the still unknown.
Mechanism of thousands of scientists working on. But how can it be absorbed he still could not find the trigger?
Relatives of the patients, and patients sometimes also ask this question. "How is it still does not cure it. Medicine, he proceeded to say" they say. But the remedy of these diseases have to say, especially to stop and turn back the mean cell death, more or less equivalent to solving the mystery of life. If you know how cell death and aging of the people in a sense, we find the way to stop him, we found a way to prevent or even die. Understand the mechanism of cell death and is responsible for it to decrypt the genetic code of life as almost solve. Supposed to do this, not that easy.
Çözseniz this disease instead of the other diseases will be considered absolutely. You know, a full fifteen-twenty years ago, the disease appeared to have never known.
Historically, when you look at this way, the War with nature is always new obstacles, we also strive to overcome them. Maybe as you say that we find solutions to these diseases other diseases, problems may occur. Then you begin to fight with them.
What is Essential Tremor Alzheimer's
Peculiar Shake: What is Essential Tremor
What is involved in the diseases?
Most of them are involved in the differential diagnosis of a disease, a condition called essential tremor. This "familial tremor", "familial tremor" in the call. Seems quite common. Essential tremor, shows a peculiar form of chills. Parkinson's disease, tremor, at rest, tremofun essential tremor occurs in the opposite motion. While at rest in patients with essential tremor tremor'lu there. If the patient is relaxed, even though his arm was on his lap or put on the table, would not be shivering. But I began to use the time to raise his hand in, for example, coffee-tea drinking, eating dinner starts to tremble. This is a tremor of Parkinson different. When you look at as a type of essential trenıor'da flicker. more subtle and quick release when there is a tremor, a tremor Parkinson'daki slow and rude. Technical terms, speaking of Parkinson's shake 5-6 hertz frequency, while the other frequency is around 11-12 hertz. Parkinson's disease patients in the community every trembling thought. Although less is known more commonly olmasma essential tremor. Flicker, sometimes mild, but sometimes can be very severe, the patient can not write at all, you can not eat. Where they stopped at about 5 percent of patients with essential tremor doom. Here is the difficulty they sometimes draw your diagnosis, I wonder this, Is essential tremor, Parkinson's Is not she? Essential tremor in the same ill Parkinsonlular heyecanlanınca like, when I am angry, happy, and even increased titremelerinin say, "No Sakinken no vibe. Evdeysem titremiyorum alone. But I have to talk to someone across the pass, my friends to bring a tray of tea state, while all eyes on me, then shake starting to say ".
Essential tremor'u, separates Parkinson's disease and other features, the two have to match? Essential Tremor ailevidir very seriously. At least two-thirds of patients say that the mother or father side of the vibrations. Such as essential tremor or Parkinson's usually begins in old age, but sometimes very young age, children can begin even at an early age, especially the prominent feature The person family. This all may continue throughout life. Essential tremor, Parkinson's, such as the amount of more than one side, that is usually asymmetrical. On the other hand, a person with the essential tremor'u, 2-3 times higher than the risk of occurrence of Parkinson's disease. Sometimes you just say good observing patients, "Mr. Doctor, I'm used to using my hand, do not ever shine, there were fine and a vibe. Now, I've been occurring anywhere in a coarser form of tremor has been added." These cases included on the essential tremor'un cases of Parkinson's disease. So sometimes the two can coexist, and often at a Parkinson's disease, essential tremor'u will follow ...
Do you have Parkinson's and other diseases are involved in it?
The second group involved in the context of the symptoms of Parkinson's disease have other diseases. Especially slowing of gait, arm, leg, to be stiff, with symptoms such as facial maskeleş-Mesi. Engaged in these diseases, to be involved with Parkinson's "Parkinson's plus syndromes (Parkinson's plus) is called. These are relatively frequent encounter one of the multi-system atrophy (MSA) or" multiple system atrophy, "we call disease. Defines the disease name is already in the nature of the disease. Parkinson's disease in the foreground, while the substantia nigra'da disorder, multi-system involvement is more common there atrofisi'nde. He let me explain with an example. Parkinson's disease, but the lamps have a problem with a solid power plant that provides electricity. He provides electricity for lights burn in the outside . Multi-system atrophy is not going as well as electric lamps have a problem. His power is given to even yanmayabiliyor lamps. It looks like Parkinson's disease, but it separates the property from him, an imbalance in some of the patients, a portion of the urinary incontinence, severe drops in blood pressure like symptoms or all of them have more than one. Also, a part of the Parkinson's patients does not respond to treatment with either no improvement or a partial and temporary shows. This is the classic Parkinson's disease, Parkinson's syndrome after the most frequently seen among the causes of degenerative type. This cousin of Parkinson's disease, or also say that a close relative. The second is a disease, PSP (progressive paralysis of eye movements). Here again, the important feature of Parkinson's table. In particular the slowdown in movement, there is rigidity, but also falls for no reason that these patients since the first years. In addition, eye movements, a starting to slow down, glance up and down, especially at the beginning, all kinds of eye movement, increasingly restricted. Another rare "degenerative Parkinson's" in the CBD of type (corticobasal ganglionic degeneration) that we call disease. Here is a table that very asymmetric and very stiff. Parkinson's disease, as well as This disease begins with the asymmetric, or even much more pronounced asymmetry. a party to a very prominent, stiff and yavaşlamışken, on the other side not find any evidence. This disease is rare and much more tremors in a few years added to the table in a form of dementia.
What is involved in the diseases?
Most of them are involved in the differential diagnosis of a disease, a condition called essential tremor. This "familial tremor", "familial tremor" in the call. Seems quite common. Essential tremor, shows a peculiar form of chills. Parkinson's disease, tremor, at rest, tremofun essential tremor occurs in the opposite motion. While at rest in patients with essential tremor tremor'lu there. If the patient is relaxed, even though his arm was on his lap or put on the table, would not be shivering. But I began to use the time to raise his hand in, for example, coffee-tea drinking, eating dinner starts to tremble. This is a tremor of Parkinson different. When you look at as a type of essential trenıor'da flicker. more subtle and quick release when there is a tremor, a tremor Parkinson'daki slow and rude. Technical terms, speaking of Parkinson's shake 5-6 hertz frequency, while the other frequency is around 11-12 hertz. Parkinson's disease patients in the community every trembling thought. Although less is known more commonly olmasma essential tremor. Flicker, sometimes mild, but sometimes can be very severe, the patient can not write at all, you can not eat. Where they stopped at about 5 percent of patients with essential tremor doom. Here is the difficulty they sometimes draw your diagnosis, I wonder this, Is essential tremor, Parkinson's Is not she? Essential tremor in the same ill Parkinsonlular heyecanlanınca like, when I am angry, happy, and even increased titremelerinin say, "No Sakinken no vibe. Evdeysem titremiyorum alone. But I have to talk to someone across the pass, my friends to bring a tray of tea state, while all eyes on me, then shake starting to say ".
Essential tremor'u, separates Parkinson's disease and other features, the two have to match? Essential Tremor ailevidir very seriously. At least two-thirds of patients say that the mother or father side of the vibrations. Such as essential tremor or Parkinson's usually begins in old age, but sometimes very young age, children can begin even at an early age, especially the prominent feature The person family. This all may continue throughout life. Essential tremor, Parkinson's, such as the amount of more than one side, that is usually asymmetrical. On the other hand, a person with the essential tremor'u, 2-3 times higher than the risk of occurrence of Parkinson's disease. Sometimes you just say good observing patients, "Mr. Doctor, I'm used to using my hand, do not ever shine, there were fine and a vibe. Now, I've been occurring anywhere in a coarser form of tremor has been added." These cases included on the essential tremor'un cases of Parkinson's disease. So sometimes the two can coexist, and often at a Parkinson's disease, essential tremor'u will follow ...
Do you have Parkinson's and other diseases are involved in it?
The second group involved in the context of the symptoms of Parkinson's disease have other diseases. Especially slowing of gait, arm, leg, to be stiff, with symptoms such as facial maskeleş-Mesi. Engaged in these diseases, to be involved with Parkinson's "Parkinson's plus syndromes (Parkinson's plus) is called. These are relatively frequent encounter one of the multi-system atrophy (MSA) or" multiple system atrophy, "we call disease. Defines the disease name is already in the nature of the disease. Parkinson's disease in the foreground, while the substantia nigra'da disorder, multi-system involvement is more common there atrofisi'nde. He let me explain with an example. Parkinson's disease, but the lamps have a problem with a solid power plant that provides electricity. He provides electricity for lights burn in the outside . Multi-system atrophy is not going as well as electric lamps have a problem. His power is given to even yanmayabiliyor lamps. It looks like Parkinson's disease, but it separates the property from him, an imbalance in some of the patients, a portion of the urinary incontinence, severe drops in blood pressure like symptoms or all of them have more than one. Also, a part of the Parkinson's patients does not respond to treatment with either no improvement or a partial and temporary shows. This is the classic Parkinson's disease, Parkinson's syndrome after the most frequently seen among the causes of degenerative type. This cousin of Parkinson's disease, or also say that a close relative. The second is a disease, PSP (progressive paralysis of eye movements). Here again, the important feature of Parkinson's table. In particular the slowdown in movement, there is rigidity, but also falls for no reason that these patients since the first years. In addition, eye movements, a starting to slow down, glance up and down, especially at the beginning, all kinds of eye movement, increasingly restricted. Another rare "degenerative Parkinson's" in the CBD of type (corticobasal ganglionic degeneration) that we call disease. Here is a table that very asymmetric and very stiff. Parkinson's disease, as well as This disease begins with the asymmetric, or even much more pronounced asymmetry. a party to a very prominent, stiff and yavaşlamışken, on the other side not find any evidence. This disease is rare and much more tremors in a few years added to the table in a form of dementia.
Information about Parkinson's Disease
Unknown Causes of Parkinson's Disease
Cause of Parkinson's disease, what do we know this? We do not know the cause of Parkinson's disease. Better understand the changes in the brain of Parkinson's disease situation. The same as in Alzheimer's disease. There was an analogy I did, "Crime location durumdayız well understood, but not yet absorbed the guilty are yet to find the trigger." Especially in the last 8-10 years, the developments in the genetics of Parkinson's disease, these cells die why we think we understand better. For example, "familial Parkinson's disease," this or that cause genetic mutations in all of the construction and destruction of proteins within cells that are associated with mutations of the genes. A protein encoded by one of these genes in Lewy cisimciğinin accumulating. Mutations in other genes in disease-causing proteins in the transformation of cells, genes involved in the collapse-making. Today at the point in the brain cells of Parkinson's patients have a problem I think in the old abolition of proteins. Proteins are constantly required the demolition of burned, and the roles of cell function and structure of the molecules in the cell. Yıprandıkları collapsed again when I need has been undertaken. If you are in any way in the cell, proteins that breaks the old system, if a problem, these obsolete proteins slowly begin to accumulate within the cell. These proteins are accumulated in a while, then they start to disrupt the normal functioning of the cell. Now you can not see the function of healthy, do not generate the necessary energy in the cell decides to commit suicide, and suicide genes are already available to run the genetic program closes its ignition. Assumption that the disease occurrence in the present.
This "contact closure" does not in some of the incident is why some people?
Current opinion, it emerges as a kind of genetic-environmental interaction. Some people from birth, some predisposition genes have brought. If the circuit enters in some environmental factors, susceptible to disease in humans is emerging. In other words, the majority of patients are not the only culprit of genetic, environmental factors are not the only culprit, the problem is a gene-environment interaction. Wrong genes in human disease risk rises with the wrong circles.
Anamnez'e again to put the diagnosis (the patient's disease, a doctor to tell his story) to apply?
Yes. A clinical diagnosis of Parkinson's disease as the principle diagnosis. You see the patient, "moving, there is a general slowdown. Walking gradually slowed down, smaller steps in. My body leaned forward.'ve Been right on my arm where there is a tremor. He am having trouble using my hand," he said, such as when the symptoms of this disease şüpheleniyorsunuz immediately. Examination findings, diagnosis, and ultimately our patients koyduruyor gözlemlediklerimiz. Patients and their relatives will be a good history of the disease, coupled with a good observation and examination to diagnose the majority of patients zorlanmıyoruz. Do you have a face which brings a patient to really shake, Do not, how titriyorsa shaking, he possesses. The tremors are usually excitement, anger or even joy arises or is increased. We also try to heyecanlandırmaya the patient during examination. During the inspection, a hand hand in a patient with neurological examination gözlerken call all the way from head to toe We review the functioning of the nervous system. We do this in a systematic also. Before we start the head and eye movements, vision, the face can be moved, hearing, sensation of the face, tongue and pharynx movements, we'll evaluate the sound and speech. Arms and legs in a certain system to review it. On the one hand we look at movement, strength, coordination, reflexes, hand, we assess the ability of small jobs. Do you have a loss of sensation, is there such a melting muscle mass does, look. After the march, review our position. As a result of all these examinations and assessments, the patient is what determines the findings. Do you really have to slow down, for example, Do you have a change in walking, his face is frozen (as we call it in the face mask), his voice has changed (a bit of Parkinson's patients in a low voice, light tone, and sometimes repeating syllables speak) identifies them. The patient's relatives said the findings of the inspection and bring together and decide whether or not Parkinson's syndrome in a patient.
Probably lies in the question of what comes under this phase of Parkinson's sendromunıın, namely the differential diagnosis: This is a classic Is Parkinson's disease, or one of its counterparts?
At this stage, we look at the thing, additional evidence suggesting Is there a similar one, to find an answer to it. That is the main sign of Parkinson's syndrome, one that extends beyond 4, a deceleration or limitation of eye movements, balance disorder, patients with severely decreased blood pressure when he stood up to have additional evidence, assess it. At the same time help başvururuz diagnostic methods, for example, brain computed tomography (CT) or magnetic resonance (MR) imaging, such as with. However, we want to make a statement which could lead to Parkinson's to exclude other causes of the brain vascular obstructions, tumors, such as the expansion of the spaces within the brain. Furthermore, the direct contribution of CT or MR would not meet the classic Parkinson's disease. That put the diagnosis of Parkinson's disease is a brain MR'ına looking at the classic.
Drug-response rate: 90-95 percent
Do you have a contribution to diagnosis of the patient's response to the treatment of Parkinson's?
One of the important findings in the differential diagnosis for us, whether you did not respond well to the treatment of Parkinson's patients. Classical Parkinson's disease, hastalanıl 90-95 percent respond positively to this or that drug. Classic Parkinson's disease, Parkinson's syndrome, which causes a large extent the relatives do not respond to treatment. In response to therapy also directs us to his diagnosis.
Cause of Parkinson's disease, what do we know this? We do not know the cause of Parkinson's disease. Better understand the changes in the brain of Parkinson's disease situation. The same as in Alzheimer's disease. There was an analogy I did, "Crime location durumdayız well understood, but not yet absorbed the guilty are yet to find the trigger." Especially in the last 8-10 years, the developments in the genetics of Parkinson's disease, these cells die why we think we understand better. For example, "familial Parkinson's disease," this or that cause genetic mutations in all of the construction and destruction of proteins within cells that are associated with mutations of the genes. A protein encoded by one of these genes in Lewy cisimciğinin accumulating. Mutations in other genes in disease-causing proteins in the transformation of cells, genes involved in the collapse-making. Today at the point in the brain cells of Parkinson's patients have a problem I think in the old abolition of proteins. Proteins are constantly required the demolition of burned, and the roles of cell function and structure of the molecules in the cell. Yıprandıkları collapsed again when I need has been undertaken. If you are in any way in the cell, proteins that breaks the old system, if a problem, these obsolete proteins slowly begin to accumulate within the cell. These proteins are accumulated in a while, then they start to disrupt the normal functioning of the cell. Now you can not see the function of healthy, do not generate the necessary energy in the cell decides to commit suicide, and suicide genes are already available to run the genetic program closes its ignition. Assumption that the disease occurrence in the present.
This "contact closure" does not in some of the incident is why some people?
Current opinion, it emerges as a kind of genetic-environmental interaction. Some people from birth, some predisposition genes have brought. If the circuit enters in some environmental factors, susceptible to disease in humans is emerging. In other words, the majority of patients are not the only culprit of genetic, environmental factors are not the only culprit, the problem is a gene-environment interaction. Wrong genes in human disease risk rises with the wrong circles.
Anamnez'e again to put the diagnosis (the patient's disease, a doctor to tell his story) to apply?
Yes. A clinical diagnosis of Parkinson's disease as the principle diagnosis. You see the patient, "moving, there is a general slowdown. Walking gradually slowed down, smaller steps in. My body leaned forward.'ve Been right on my arm where there is a tremor. He am having trouble using my hand," he said, such as when the symptoms of this disease şüpheleniyorsunuz immediately. Examination findings, diagnosis, and ultimately our patients koyduruyor gözlemlediklerimiz. Patients and their relatives will be a good history of the disease, coupled with a good observation and examination to diagnose the majority of patients zorlanmıyoruz. Do you have a face which brings a patient to really shake, Do not, how titriyorsa shaking, he possesses. The tremors are usually excitement, anger or even joy arises or is increased. We also try to heyecanlandırmaya the patient during examination. During the inspection, a hand hand in a patient with neurological examination gözlerken call all the way from head to toe We review the functioning of the nervous system. We do this in a systematic also. Before we start the head and eye movements, vision, the face can be moved, hearing, sensation of the face, tongue and pharynx movements, we'll evaluate the sound and speech. Arms and legs in a certain system to review it. On the one hand we look at movement, strength, coordination, reflexes, hand, we assess the ability of small jobs. Do you have a loss of sensation, is there such a melting muscle mass does, look. After the march, review our position. As a result of all these examinations and assessments, the patient is what determines the findings. Do you really have to slow down, for example, Do you have a change in walking, his face is frozen (as we call it in the face mask), his voice has changed (a bit of Parkinson's patients in a low voice, light tone, and sometimes repeating syllables speak) identifies them. The patient's relatives said the findings of the inspection and bring together and decide whether or not Parkinson's syndrome in a patient.
Probably lies in the question of what comes under this phase of Parkinson's sendromunıın, namely the differential diagnosis: This is a classic Is Parkinson's disease, or one of its counterparts?
At this stage, we look at the thing, additional evidence suggesting Is there a similar one, to find an answer to it. That is the main sign of Parkinson's syndrome, one that extends beyond 4, a deceleration or limitation of eye movements, balance disorder, patients with severely decreased blood pressure when he stood up to have additional evidence, assess it. At the same time help başvururuz diagnostic methods, for example, brain computed tomography (CT) or magnetic resonance (MR) imaging, such as with. However, we want to make a statement which could lead to Parkinson's to exclude other causes of the brain vascular obstructions, tumors, such as the expansion of the spaces within the brain. Furthermore, the direct contribution of CT or MR would not meet the classic Parkinson's disease. That put the diagnosis of Parkinson's disease is a brain MR'ına looking at the classic.
Drug-response rate: 90-95 percent
Do you have a contribution to diagnosis of the patient's response to the treatment of Parkinson's?
One of the important findings in the differential diagnosis for us, whether you did not respond well to the treatment of Parkinson's patients. Classical Parkinson's disease, hastalanıl 90-95 percent respond positively to this or that drug. Classic Parkinson's disease, Parkinson's syndrome, which causes a large extent the relatives do not respond to treatment. In response to therapy also directs us to his diagnosis.
Causes of Parkinson's and Alzheimer's Disease
Reasons for the emergence of Parkinson's disease, Parkinson's Reasons
Disease, Parkinson's disease, dementia, and mental dysfunction reveals a unique but very relevant in this age. James Parkinson's disease, almost all young people. These symptoms, or they had an eye for him çarpmıyordu yet. But the last twenty years, we realized that more and more well-off act out the symptoms of Parkinson's disease symptoms related to the movement there are signs of what we call a number. For example, if the precision is applied to mental tests, as a group of Parkinson's disease patients, matched for age and education show a worse performance than the normals kıyaslandıklarında. Which areas of the wicked people? Attentional, concentration, executive functions and to plan call öngörebilme ability. Word fluency than the weaker. Parkinson's patients, including young ones, inward directed attention, in part, we call attention to export oriented functions are affected in particular.
Elderly patients, especially in the 70-80 years of age, the majority of Parkinson's disease and mental deterioration occurring over time is developing a form of dementia. In the last five-six years, I also worked on a particular topic. Two years ago, an international trial of a drug that provides improvement in the treatment of these patients also describe a certain extent. Parkinson's disease, dementia, a unique dementia, Alzheimer's disease are different, and therefore show different symptoms. Alzheimer's disease and memory disorders Front plandayken, Parkinson'lularda attention impairment, concentration impairment, executive dysfunction in the foreground. In addition, these patients often dreams, delusions, frequent daytime sleepiness, are symptoms such as night sleep, talk and act. Depression in Parkinson's disease is more common than dementia.
Depression is accompanied by
How often this is seen in patients with depression my teacher?
During the course of the disease, depression emerges in one of every two patients. Human he might think: "These persistent, slowly progressive, over the years with a chronic disease caused by the loss of certain functional. Thus, the depression is natural." But because it is so simple it seems that the change in depression. Because Parkinson's disease, such as for example, joint arthritis, chronic involvement and the loss of function, compared to other diseases, seems to be a higher rate of depression in Parkinson's patients. Based on this observation that depression is at least partly caused by the disease due to loss of brain cell believe that. For example, the classic depression in patients with decreased levels of the brain thought to substances such as serotonin and noradrenaline in patients with low-level depression has developed Parkinson's.
The third group concerns the mind and the mind as a symptom of Parkinson's disease psychosis is possible to speak of. Psychosis with illusions, hallucinations and delusions are referring to. These are usually at the beginning of the disease does not occur. I! e mean by delusions, false beliefs. For instance, "My wife is cheating on me, stealing my money, my children wants to get rid of me like" thoughts. I mean a different perception of the illusion of an existing alert. For example, a hat hanging askılıkta, but the patient, sees him as a head. There are in fact an object, there is a visual warning, but the patient perceives it different. Hallucinations (dream), the no non-detection of a stimulus, for example, are no items in common, but the patient "a man sitting on the couch" when there is no sound is heard, or "knock on the door, the phone rang, someone said," such as the perceived non-sensory warnings. Sometimes it is a common disorder in the other sensing "the presence of a body" feeling. The patient says, "It feels like there is one room, as if someone is standing behind me, as I look, there is not anybody."
All this is very rarely seen the first years of the patient. Approximately 70 percent of patients with dementia-type symptoms that are emerging. In some patients, drugs are seen as a side effect. In fact, the majority of drugs available for treatment of Parkinson's disease, especially in high doses can cause dreams
Parkinson's Alzheimer's
Alzheimer'dan more promising
Parkinson's disease in the brain exactly what's going on? The most characteristic feature of Parkinson's disease, our "brain stem" region that we call the two-sided, symmetrical settled as "black core" (substantia nigra) is considered as the formation of a cell group, degeneration and cell loss. Black core, within the small number, the cell contains around 800 thousand. For the emergence of the symptoms of Parkinson's disease, these cells have lost at least 60 percent-70. This means that in fact the disease, begins long before symptoms occur. With special imaging techniques to show the loss of these cells is also possible. This is a slowly progressive loss of cells. Reserve system, but all of the cells to be more than a backup 60'mı percent, after losing 70 percent of the symptoms are beginning to emerge. There are people in their lifetime so it did not show any symptom of Parkinson's, had died for no other reason. When examining the brains of cell loss was seen that there is 50 percent black and the nucleus. In other words, half lost in all the cells, whereas no signs of undisclosed. Besides the loss of this cell is a kind of black core protein in the cells see a ball of accumulated. However we "Lewy Apparatus" call. Discovered took the name of the German pathologist. This is very characteristic for Parkinson's disease, a finding essential. This cell loss in Parkinson's disease, the emergence of movement disorders related cause. Black kernel cells produce a chemical called dopamine. Dopamine, the neurotransmitter that we call our group, one of the substances used to provide communication among brain cells. A cell, to give a message to someone else at any time, one of these substances secreted, go to the second cell in the chemical sensors of its own previous warning and the first cell to cell, is the second outgoing message. Here we call these substances norotransmitter'ler or neurochemicals. Dopamine is one of them and the movement of a substance required for initiation and be in harmony. Dopamine, found in the black core is made of cells and their extensions through the basal ganglion'lar we say, deep in the brain, large cell groups located on both sides is being transmitted. After this has taken place, we start our movement so we can make a smooth and harmonious. This matter is the lack of dopamine in the cells died.
So does the lack of dopamine in this disease?
Yes, most of the major symptoms of Parkinson's disease related movement responsible for the lack of dopamine. Patients, a lack of dopamine, the more movement is so much about the problems. In particular, slow movement, muscle stiffness directly related to the amount of dopamine.
Between the severity of shivering with the black kernel of the direct reduction of dopamine, a proportion do not have one to one.
Disease, Parkinson's disease, dementia, and mental dysfunction reveals a unique but very relevant in this age. James Parkinson's disease, almost all young people. These symptoms, or they had an eye for him çarpmıyordu yet. But the last twenty years, we realized that more and more well-off act out the symptoms of Parkinson's disease symptoms related to the movement there are signs of what we call a number. For example, if the precision is applied to mental tests, as a group of Parkinson's disease patients, matched for age and education show a worse performance than the normals kıyaslandıklarında. Which areas of the wicked people? Attentional, concentration, executive functions and to plan call öngörebilme ability. Word fluency than the weaker. Parkinson's patients, including young ones, inward directed attention, in part, we call attention to export oriented functions are affected in particular.
Elderly patients, especially in the 70-80 years of age, the majority of Parkinson's disease and mental deterioration occurring over time is developing a form of dementia. In the last five-six years, I also worked on a particular topic. Two years ago, an international trial of a drug that provides improvement in the treatment of these patients also describe a certain extent. Parkinson's disease, dementia, a unique dementia, Alzheimer's disease are different, and therefore show different symptoms. Alzheimer's disease and memory disorders Front plandayken, Parkinson'lularda attention impairment, concentration impairment, executive dysfunction in the foreground. In addition, these patients often dreams, delusions, frequent daytime sleepiness, are symptoms such as night sleep, talk and act. Depression in Parkinson's disease is more common than dementia.
Depression is accompanied by
How often this is seen in patients with depression my teacher?
During the course of the disease, depression emerges in one of every two patients. Human he might think: "These persistent, slowly progressive, over the years with a chronic disease caused by the loss of certain functional. Thus, the depression is natural." But because it is so simple it seems that the change in depression. Because Parkinson's disease, such as for example, joint arthritis, chronic involvement and the loss of function, compared to other diseases, seems to be a higher rate of depression in Parkinson's patients. Based on this observation that depression is at least partly caused by the disease due to loss of brain cell believe that. For example, the classic depression in patients with decreased levels of the brain thought to substances such as serotonin and noradrenaline in patients with low-level depression has developed Parkinson's.
The third group concerns the mind and the mind as a symptom of Parkinson's disease psychosis is possible to speak of. Psychosis with illusions, hallucinations and delusions are referring to. These are usually at the beginning of the disease does not occur. I! e mean by delusions, false beliefs. For instance, "My wife is cheating on me, stealing my money, my children wants to get rid of me like" thoughts. I mean a different perception of the illusion of an existing alert. For example, a hat hanging askılıkta, but the patient, sees him as a head. There are in fact an object, there is a visual warning, but the patient perceives it different. Hallucinations (dream), the no non-detection of a stimulus, for example, are no items in common, but the patient "a man sitting on the couch" when there is no sound is heard, or "knock on the door, the phone rang, someone said," such as the perceived non-sensory warnings. Sometimes it is a common disorder in the other sensing "the presence of a body" feeling. The patient says, "It feels like there is one room, as if someone is standing behind me, as I look, there is not anybody."
All this is very rarely seen the first years of the patient. Approximately 70 percent of patients with dementia-type symptoms that are emerging. In some patients, drugs are seen as a side effect. In fact, the majority of drugs available for treatment of Parkinson's disease, especially in high doses can cause dreams
Parkinson's Alzheimer's
Alzheimer'dan more promising
Parkinson's disease in the brain exactly what's going on? The most characteristic feature of Parkinson's disease, our "brain stem" region that we call the two-sided, symmetrical settled as "black core" (substantia nigra) is considered as the formation of a cell group, degeneration and cell loss. Black core, within the small number, the cell contains around 800 thousand. For the emergence of the symptoms of Parkinson's disease, these cells have lost at least 60 percent-70. This means that in fact the disease, begins long before symptoms occur. With special imaging techniques to show the loss of these cells is also possible. This is a slowly progressive loss of cells. Reserve system, but all of the cells to be more than a backup 60'mı percent, after losing 70 percent of the symptoms are beginning to emerge. There are people in their lifetime so it did not show any symptom of Parkinson's, had died for no other reason. When examining the brains of cell loss was seen that there is 50 percent black and the nucleus. In other words, half lost in all the cells, whereas no signs of undisclosed. Besides the loss of this cell is a kind of black core protein in the cells see a ball of accumulated. However we "Lewy Apparatus" call. Discovered took the name of the German pathologist. This is very characteristic for Parkinson's disease, a finding essential. This cell loss in Parkinson's disease, the emergence of movement disorders related cause. Black kernel cells produce a chemical called dopamine. Dopamine, the neurotransmitter that we call our group, one of the substances used to provide communication among brain cells. A cell, to give a message to someone else at any time, one of these substances secreted, go to the second cell in the chemical sensors of its own previous warning and the first cell to cell, is the second outgoing message. Here we call these substances norotransmitter'ler or neurochemicals. Dopamine is one of them and the movement of a substance required for initiation and be in harmony. Dopamine, found in the black core is made of cells and their extensions through the basal ganglion'lar we say, deep in the brain, large cell groups located on both sides is being transmitted. After this has taken place, we start our movement so we can make a smooth and harmonious. This matter is the lack of dopamine in the cells died.
So does the lack of dopamine in this disease?
Yes, most of the major symptoms of Parkinson's disease related movement responsible for the lack of dopamine. Patients, a lack of dopamine, the more movement is so much about the problems. In particular, slow movement, muscle stiffness directly related to the amount of dopamine.
Between the severity of shivering with the black kernel of the direct reduction of dopamine, a proportion do not have one to one.
Symptoms of Parkinson's Disease
There are 4 main symptoms of Parkinson's disease
Now, the main symptoms of Parkinson's disease, if you want to talk about.
In medicine, "Parkinson's syndrome" and "differentiating between Parkinson's disease. Medicine in the language of" syndrome "is a combination of symptoms caused by a group of so-called entity. Under any of a syndrome of different reasons, lie in different diseases. There are signs of Parkinson's syndrome, 4-. The first one is ; movements slow down. slowdown in the movement of movements of all kinds such as a depletion function, slowdown, slowdown occurs. For example, a difficulty in using his hand, a muff, a slow start to feel sick, "I'm writing, I realize my summer has started to shrink gradually. Difficult to pull off the buttons feel especially close. Opening and closing the caps, turning movements, while shaving a muff, I feel a slowdown, "he says. As I mentioned above, the patient himself gözlemleyebiliyorsa good, overall strength is actually not a problem, but using the hand, there is a problem in making movements in-coherent and consistent manner describes. If the disease began to arm, the patient's symptoms usually say like that. The disease may begin in the leg. This time, the patient says, "I'm like a leg sürter, am having trouble removing a foot. Especially while the high steps, and sometimes it comes back foot, gets stuck. "Ministers from the outside of the patient walking on a side arm may notice sallamadığını. All these are the number one symptom of Parkinson's syndrome to slow down the movements, as in the language of medicine, the symptoms of bradikinezi'nin.
number two, what symptoms?
There is a basic rate of contraction of all muscles is normally mild. We call it "muscle tone" call. Parkinson's syndrome, increases muscle tone. When a patient's arm or leg oynattığımız away, you'll notice that resisted. It is a lead pipe bükermişçesine, resistance throughout the entire movement. Patients do, muscle aches, muscle stiffness perceive as. Medicine in the language we call it rigidity.
Tip number one symptom that famous or chills?
Yes, I own a typical tremor. This occurs when a coarse resting tremor, and in principle. No not using the patient's leg or arm, for example, in the form of oscillations in addition to rough handling or a tremor in her arms. Sometimes the only sign with the thumb-finger holds. We call it "counting the money in the form of tremors," or "shivering in the form of a pill to" call. Sometimes it is light enough to realize that as soon as the patient himself. Recognize relatives, "Your hands are shaking," they say. The patient looks at the acts of his hand trembling. In general, use of hands lifted when initiated, the chills, even if temporarily lost the hand or arm continues to keep a certain position may occur again. Therefore, the majority of patients, if not too severe, movements you do not complain. Vibration creates an inconvenience for the patient, rather than compromising the patient's functions. Reluctant to come out into the community for others to refrain would see. In the language of medicine in this "resting tremor" call.
Main symptoms of Parkinson's Syndrome
Slowing of gait and movements, tutuklaşması, and fine works have difficulty in initiating movement, tarnish percent (bradykinesia)
Muscle stiffness (rigidity)
Resting on the hand or leg shaking (tremor)
Posture and balance in impaired reflexes, the body bending forward (postural disorder)
What about the fourth symptom?
In the fourth symptom of Parkinson's syndrome, the body's posture and grip reflexes deterioration. A continuous contraction of muscles against gravity while standing in humans, plant and equipment, and our "stand-grip reflexes" collapsed like a sack of people who had not been what we call kalırlardı reflexes. Basic reflex to us and the basic "muscle tone" keeps us alive. Subjected to a distorting effect on balance when we suddenly lets düşmememizi. For example, someone standing motionless, just take a backward throws a leg backwards, again, the balance of his arms forward and provides savurur. We call it "reflex catch" call. Parkinson's syndrome is a problem with this stance and grip reflexes. Parkinson's patients for it when itelediğiniz, somewhere towards the back foot can collapse atamayıp. We call it the language of np "postural reflex disorder" or "postural disturbance" call. Similarly, out-patients a deterioration occurs in stances. Patients are typically very forward, curved stand, twisting their arms to the right was taken lightly. At first glance, such a patient to recognize on sight. When balance is impaired in any way in these patients, the patient returns to its normal position may fall sağlayamayıp. That patients sometimes are described as follows: "the bus was standing, suddenly moved. Yapamadan nothing fell like a log" or, "more than my balance was going down hill sağlayamadım, pushed me from behind and I fell like the one I started to accelerate."
These 4 symptoms when combined, we are a "Parkinson's syndrome" of, or in other words, we say that there is Parkinsoniztn'in. However, symptoms of Parkinson's syndrome, this 4-in-one to say that is not necessary. One of them is a minimum of 2 aradaysa "Parkinson's syndrome" is diagnosed.
Now let's Parkinson's disease ... The most common underlying cause of Parkinson's syndrome;
Parkinson's disease. If we give a ratio of roughly 10 patients, 8 of them the underlying cause of Parkinson's table showing the "classical (idiopathic) Parkinson's disease. The remaining two patients, we find other reasons. The reason we collect under two different titles. The first group of diseases characterized by loss of brain cells or" neurodegenerative diseases. "The second group, which causes symptomatic disease or Parkinson belirtisel. These are a direct result of brain cell loss did not occur, but another cause of disease or Parkinson's statements as a result of the brain affect certain regions. This group, for example in food poisoning (mercury poisoning, manganese poisoning, sometimes organic phosphate poisoning), certain infections, certain medications, trauma, or have a brain vessel occlusion. These are the brain regions required for movement in unison and harmony, they can damage that may be of a Parkinson's table.
The resulting loss of brain cells of Parkinson's table of the big band does?
Yes, they are differentiating the two. The first and most often the one mentioned above, "idiopathic (unknown cause) or the classic Parkinson's disease. All of this cause in 80 percent of patients with Parkinson's tables. The other group of the Parkinson's plus" or "Parkinson's plus" syndrome that we call the group. Isimlendirmemizin this reason, this group of 4 main symptom of Parkinson's syndrome, the symptoms of diseases to be added to the other. For example, eye movements, with or slow down, donuklaşması said. with or slow down with a serious loss of balance in the movements in question. with or next to the classic Parkinson's symptoms included low blood pressure or urinary incontinence is a very serious question subject.
So how is starting and developing Parkinson's disease?
90-in 95 percent of patients with Parkinson's disease on one side of the body, arm or leg begins. Over the years, gradually going through the other side. Onset can vary from patient to patient. Some patients are starting to flicker. Ability or the ability of the foot problem does not yet used. In the majority of patients, not shivering, whereas a decrease in ability to hand, iliklerken buttons, feels a difficulty when writing: "I have a stiffness, difficulty shaving becomes," or, "I would do fine embroidery, now began to wear my hand" in the form . Some patients with arm or leg is not starting. The patient began a foot rub, "he says. In fact, some patients say carefully," the tip of my shoes look a bit more worn out party, the more worn out. "There is an interesting observation. The disease sometimes can start with shoulder and arm pain. This movement think it is a symptom of his slow and stiffness. In time, other symptoms are also added to it.
So there is no steady Is Parkinson's disease patients? Parkinson's may be called at least does not flicker?
No attempt. Not have to be trembling in Parkinson's disease. So for patients, however, no titremiyorlar disease. Sometimes we are the wrong perception by patients' relatives. They say, "Doctor Bey, but you never titremiyorum I have Parkinson's." We usually depending on the nature of symptoms of Parkinson's patients with the clinical picture in the foreground are dedicating two main types. First, the dominant type of tremor, the second, the dominant type of slow-jamming. In general, all during the course of the disease, even if this dominance is protected over the years. Shivering tremor for many years, starting with the dominant type of patients they keep. But over time eliminate kalkabiliyor chills, or tremors can be added over time in patients starting tutuklukla. That is the dominant symptom of patients with type vary, but generally keeps the dominant type for years and years.
Parkinson's disease, a slowly progressing fast enough. In some patients a few years the situation remained unchanged in some patients where they değişebiliyorlar faster. Shows the change in the course of the disease from person to person. In other words, so to speak, each patient has Parkinson's disease is a peculiar.
Makes Symptoms of Parkinson's Disease
Of selective cell death of brain diseases (neurodegenerative diseases)
Idiopathic (classical), Parkinson's disease
"Parkinson-plus" diseases that cause loss
Cell loss affects more than one system (multi-system atrophy)
Common Levvy bodies disease (dementia with Lewy bodies, diffuse Levvy body disease)
Huntington's disease
Progressive paralysis of eye movements (progressive supranuclear paresis)
Corticobasal ganglionic degeneration
Parkinsonism due to secondary causes
Due to small vessel disease of the brain (vascular) parkinsonism
Parkinsonism due to poisoning (eg, manganese, mercury)
Parkinsonism due to brain infection
Parkinsonism due to brain tumors
Traumatic Parkinsonism
Parkinsonism due to drugs (eg antipsychotics)
Parkinsonism due to metabolic diseases
Other reasons
Do not have the disease, the patient has
At that time, not the disease is still here, do you treat a patient? ..
Exactly. The general rule in medicine also applies here: "There is no disease, the patient has." We use tables to yönlenmek disease diagnosis, they are directing us to certain directions, daraltıyorlar possibilities.
So how many if your patient, you mean so much Do you have Parkinson's?
Absolutely. You can even explain with an example like this. All the people on the fact there is a very simple elements: eyes, nose, mouth and ears. There are four elements that make up the face of roughly you can say. But their coming together in a very different shape. This difference makes people very different from each other's face. So does this think of. Yes, there are four main symptoms of this disease, but their coming together in the emergence and shape is different from patient to patient. For him, the general rule in medicine for us is: "do not have the disease, the patient has."
Do you have symptoms related to memory?
In fact, a British scientist, James Parkinson's disease for the first time in 1817 defines the "slow movement of these patients. They pull difficulty initiating movement. Katılaşıyor muscles, there is judder. But the intelligence and senses remain unchanged," he says. However, in recent years we realized that better mental function and mood in patients with PD and is related to the symptoms. James Parkinson, a gözlemciyken I wonder how well this is it jumped? I think not.
Now, the main symptoms of Parkinson's disease, if you want to talk about.
In medicine, "Parkinson's syndrome" and "differentiating between Parkinson's disease. Medicine in the language of" syndrome "is a combination of symptoms caused by a group of so-called entity. Under any of a syndrome of different reasons, lie in different diseases. There are signs of Parkinson's syndrome, 4-. The first one is ; movements slow down. slowdown in the movement of movements of all kinds such as a depletion function, slowdown, slowdown occurs. For example, a difficulty in using his hand, a muff, a slow start to feel sick, "I'm writing, I realize my summer has started to shrink gradually. Difficult to pull off the buttons feel especially close. Opening and closing the caps, turning movements, while shaving a muff, I feel a slowdown, "he says. As I mentioned above, the patient himself gözlemleyebiliyorsa good, overall strength is actually not a problem, but using the hand, there is a problem in making movements in-coherent and consistent manner describes. If the disease began to arm, the patient's symptoms usually say like that. The disease may begin in the leg. This time, the patient says, "I'm like a leg sürter, am having trouble removing a foot. Especially while the high steps, and sometimes it comes back foot, gets stuck. "Ministers from the outside of the patient walking on a side arm may notice sallamadığını. All these are the number one symptom of Parkinson's syndrome to slow down the movements, as in the language of medicine, the symptoms of bradikinezi'nin.
number two, what symptoms?
There is a basic rate of contraction of all muscles is normally mild. We call it "muscle tone" call. Parkinson's syndrome, increases muscle tone. When a patient's arm or leg oynattığımız away, you'll notice that resisted. It is a lead pipe bükermişçesine, resistance throughout the entire movement. Patients do, muscle aches, muscle stiffness perceive as. Medicine in the language we call it rigidity.
Tip number one symptom that famous or chills?
Yes, I own a typical tremor. This occurs when a coarse resting tremor, and in principle. No not using the patient's leg or arm, for example, in the form of oscillations in addition to rough handling or a tremor in her arms. Sometimes the only sign with the thumb-finger holds. We call it "counting the money in the form of tremors," or "shivering in the form of a pill to" call. Sometimes it is light enough to realize that as soon as the patient himself. Recognize relatives, "Your hands are shaking," they say. The patient looks at the acts of his hand trembling. In general, use of hands lifted when initiated, the chills, even if temporarily lost the hand or arm continues to keep a certain position may occur again. Therefore, the majority of patients, if not too severe, movements you do not complain. Vibration creates an inconvenience for the patient, rather than compromising the patient's functions. Reluctant to come out into the community for others to refrain would see. In the language of medicine in this "resting tremor" call.
Main symptoms of Parkinson's Syndrome
Slowing of gait and movements, tutuklaşması, and fine works have difficulty in initiating movement, tarnish percent (bradykinesia)
Muscle stiffness (rigidity)
Resting on the hand or leg shaking (tremor)
Posture and balance in impaired reflexes, the body bending forward (postural disorder)
What about the fourth symptom?
In the fourth symptom of Parkinson's syndrome, the body's posture and grip reflexes deterioration. A continuous contraction of muscles against gravity while standing in humans, plant and equipment, and our "stand-grip reflexes" collapsed like a sack of people who had not been what we call kalırlardı reflexes. Basic reflex to us and the basic "muscle tone" keeps us alive. Subjected to a distorting effect on balance when we suddenly lets düşmememizi. For example, someone standing motionless, just take a backward throws a leg backwards, again, the balance of his arms forward and provides savurur. We call it "reflex catch" call. Parkinson's syndrome is a problem with this stance and grip reflexes. Parkinson's patients for it when itelediğiniz, somewhere towards the back foot can collapse atamayıp. We call it the language of np "postural reflex disorder" or "postural disturbance" call. Similarly, out-patients a deterioration occurs in stances. Patients are typically very forward, curved stand, twisting their arms to the right was taken lightly. At first glance, such a patient to recognize on sight. When balance is impaired in any way in these patients, the patient returns to its normal position may fall sağlayamayıp. That patients sometimes are described as follows: "the bus was standing, suddenly moved. Yapamadan nothing fell like a log" or, "more than my balance was going down hill sağlayamadım, pushed me from behind and I fell like the one I started to accelerate."
These 4 symptoms when combined, we are a "Parkinson's syndrome" of, or in other words, we say that there is Parkinsoniztn'in. However, symptoms of Parkinson's syndrome, this 4-in-one to say that is not necessary. One of them is a minimum of 2 aradaysa "Parkinson's syndrome" is diagnosed.
Now let's Parkinson's disease ... The most common underlying cause of Parkinson's syndrome;
Parkinson's disease. If we give a ratio of roughly 10 patients, 8 of them the underlying cause of Parkinson's table showing the "classical (idiopathic) Parkinson's disease. The remaining two patients, we find other reasons. The reason we collect under two different titles. The first group of diseases characterized by loss of brain cells or" neurodegenerative diseases. "The second group, which causes symptomatic disease or Parkinson belirtisel. These are a direct result of brain cell loss did not occur, but another cause of disease or Parkinson's statements as a result of the brain affect certain regions. This group, for example in food poisoning (mercury poisoning, manganese poisoning, sometimes organic phosphate poisoning), certain infections, certain medications, trauma, or have a brain vessel occlusion. These are the brain regions required for movement in unison and harmony, they can damage that may be of a Parkinson's table.
The resulting loss of brain cells of Parkinson's table of the big band does?
Yes, they are differentiating the two. The first and most often the one mentioned above, "idiopathic (unknown cause) or the classic Parkinson's disease. All of this cause in 80 percent of patients with Parkinson's tables. The other group of the Parkinson's plus" or "Parkinson's plus" syndrome that we call the group. Isimlendirmemizin this reason, this group of 4 main symptom of Parkinson's syndrome, the symptoms of diseases to be added to the other. For example, eye movements, with or slow down, donuklaşması said. with or slow down with a serious loss of balance in the movements in question. with or next to the classic Parkinson's symptoms included low blood pressure or urinary incontinence is a very serious question subject.
So how is starting and developing Parkinson's disease?
90-in 95 percent of patients with Parkinson's disease on one side of the body, arm or leg begins. Over the years, gradually going through the other side. Onset can vary from patient to patient. Some patients are starting to flicker. Ability or the ability of the foot problem does not yet used. In the majority of patients, not shivering, whereas a decrease in ability to hand, iliklerken buttons, feels a difficulty when writing: "I have a stiffness, difficulty shaving becomes," or, "I would do fine embroidery, now began to wear my hand" in the form . Some patients with arm or leg is not starting. The patient began a foot rub, "he says. In fact, some patients say carefully," the tip of my shoes look a bit more worn out party, the more worn out. "There is an interesting observation. The disease sometimes can start with shoulder and arm pain. This movement think it is a symptom of his slow and stiffness. In time, other symptoms are also added to it.
So there is no steady Is Parkinson's disease patients? Parkinson's may be called at least does not flicker?
No attempt. Not have to be trembling in Parkinson's disease. So for patients, however, no titremiyorlar disease. Sometimes we are the wrong perception by patients' relatives. They say, "Doctor Bey, but you never titremiyorum I have Parkinson's." We usually depending on the nature of symptoms of Parkinson's patients with the clinical picture in the foreground are dedicating two main types. First, the dominant type of tremor, the second, the dominant type of slow-jamming. In general, all during the course of the disease, even if this dominance is protected over the years. Shivering tremor for many years, starting with the dominant type of patients they keep. But over time eliminate kalkabiliyor chills, or tremors can be added over time in patients starting tutuklukla. That is the dominant symptom of patients with type vary, but generally keeps the dominant type for years and years.
Parkinson's disease, a slowly progressing fast enough. In some patients a few years the situation remained unchanged in some patients where they değişebiliyorlar faster. Shows the change in the course of the disease from person to person. In other words, so to speak, each patient has Parkinson's disease is a peculiar.
Makes Symptoms of Parkinson's Disease
Of selective cell death of brain diseases (neurodegenerative diseases)
Idiopathic (classical), Parkinson's disease
"Parkinson-plus" diseases that cause loss
Cell loss affects more than one system (multi-system atrophy)
Common Levvy bodies disease (dementia with Lewy bodies, diffuse Levvy body disease)
Huntington's disease
Progressive paralysis of eye movements (progressive supranuclear paresis)
Corticobasal ganglionic degeneration
Parkinsonism due to secondary causes
Due to small vessel disease of the brain (vascular) parkinsonism
Parkinsonism due to poisoning (eg, manganese, mercury)
Parkinsonism due to brain infection
Parkinsonism due to brain tumors
Traumatic Parkinsonism
Parkinsonism due to drugs (eg antipsychotics)
Parkinsonism due to metabolic diseases
Other reasons
Do not have the disease, the patient has
At that time, not the disease is still here, do you treat a patient? ..
Exactly. The general rule in medicine also applies here: "There is no disease, the patient has." We use tables to yönlenmek disease diagnosis, they are directing us to certain directions, daraltıyorlar possibilities.
So how many if your patient, you mean so much Do you have Parkinson's?
Absolutely. You can even explain with an example like this. All the people on the fact there is a very simple elements: eyes, nose, mouth and ears. There are four elements that make up the face of roughly you can say. But their coming together in a very different shape. This difference makes people very different from each other's face. So does this think of. Yes, there are four main symptoms of this disease, but their coming together in the emergence and shape is different from patient to patient. For him, the general rule in medicine for us is: "do not have the disease, the patient has."
Do you have symptoms related to memory?
In fact, a British scientist, James Parkinson's disease for the first time in 1817 defines the "slow movement of these patients. They pull difficulty initiating movement. Katılaşıyor muscles, there is judder. But the intelligence and senses remain unchanged," he says. However, in recent years we realized that better mental function and mood in patients with PD and is related to the symptoms. James Parkinson, a gözlemciyken I wonder how well this is it jumped? I think not.
Parkinson's Disease Parkinson's Syndrome
Parkinson's Disease, Parkinson's Syndrome
Sir, another important brain in Parkinson's disease. Familiar with the famous boxer Muhammad Ali with the disease. Many other famous caught the disease. Actor Michael J. Fox, Pope John Paul II. John Paul, even Adolf Hitler, the well-known Parkinson's disease. What is Parkinson's disease? Parkinson's disease, a brain disease, the brain's "neuro-degenerative," ie, selective cell loss and diseases that affect the movement of a number of diseases. All of this disease affected the brain. Especially in the initial stages of a very limited brain cell death in question. In this region, and in accordance with movements in a region which provides a streamlined way. When affected by the fluid movements, is not compatible, it becomes stiff. Force production in Parkinson's disease, the muscles do not have the power problem. The problem is the muscle force generated, the use of force. Patients with good watching them, they will say, "In fact, shes alright kuvvetimde.'s Stone sıksam çıkartabiliyorum water but to use my hand, I'm having trouble with the capability of hand."
Parkinson's name come from? What is Parkinson's
Parkinson's disease, 19 described by a British physician named James Parkinson in the early century. James Parkinson, an interesting human being. A very good observer. Both the doctor and naturalist, and politician. Even under a different name in a newspaper that writes political articles, against the monarchy. Dr. Parkinson's disease, a similar table of six or seven patients, a group of symptoms is lurking, and it appeared in an article in the medical publishing. He says, "These patients tremble, on the other hand have a problem with movement. To walk slower, smaller steps, their bodies bent forward to." Today we refer to as Parkinson's disease is described very clearly all the characteristics of the table. First described the symptoms of the disease in the medical literature referring to the human being in the name of this disease called Parkinson's disease.
So, earlier this disease is to observe, do not define anyone?
If we look back on, for example, from the medical notes in the 1500 niteleyebileceğimiz today as Parkinson's disease patients have recipes. Age is a disease occurring more and more people in previous centuries, life expectancy, probably because it is often not seen as little as 25-30 years.
In fact, not a coincidence, it is possible to identify patients who will not have olmasaymıs disease ...
Another great scientist has a good word. Pasteur says, - "Luck, trained heads but help." Chance to pass into the hands of many people, but the chance to use that only trained heads can create something from him. The masterminds of these people are good observers, to bring together the different findings in patients gözledikleri determinations in common, and so developers can describe a table that is coming.
Sir, another important brain in Parkinson's disease. Familiar with the famous boxer Muhammad Ali with the disease. Many other famous caught the disease. Actor Michael J. Fox, Pope John Paul II. John Paul, even Adolf Hitler, the well-known Parkinson's disease. What is Parkinson's disease? Parkinson's disease, a brain disease, the brain's "neuro-degenerative," ie, selective cell loss and diseases that affect the movement of a number of diseases. All of this disease affected the brain. Especially in the initial stages of a very limited brain cell death in question. In this region, and in accordance with movements in a region which provides a streamlined way. When affected by the fluid movements, is not compatible, it becomes stiff. Force production in Parkinson's disease, the muscles do not have the power problem. The problem is the muscle force generated, the use of force. Patients with good watching them, they will say, "In fact, shes alright kuvvetimde.'s Stone sıksam çıkartabiliyorum water but to use my hand, I'm having trouble with the capability of hand."
Parkinson's name come from? What is Parkinson's
Parkinson's disease, 19 described by a British physician named James Parkinson in the early century. James Parkinson, an interesting human being. A very good observer. Both the doctor and naturalist, and politician. Even under a different name in a newspaper that writes political articles, against the monarchy. Dr. Parkinson's disease, a similar table of six or seven patients, a group of symptoms is lurking, and it appeared in an article in the medical publishing. He says, "These patients tremble, on the other hand have a problem with movement. To walk slower, smaller steps, their bodies bent forward to." Today we refer to as Parkinson's disease is described very clearly all the characteristics of the table. First described the symptoms of the disease in the medical literature referring to the human being in the name of this disease called Parkinson's disease.
So, earlier this disease is to observe, do not define anyone?
If we look back on, for example, from the medical notes in the 1500 niteleyebileceğimiz today as Parkinson's disease patients have recipes. Age is a disease occurring more and more people in previous centuries, life expectancy, probably because it is often not seen as little as 25-30 years.
In fact, not a coincidence, it is possible to identify patients who will not have olmasaymıs disease ...
Another great scientist has a good word. Pasteur says, - "Luck, trained heads but help." Chance to pass into the hands of many people, but the chance to use that only trained heads can create something from him. The masterminds of these people are good observers, to bring together the different findings in patients gözledikleri determinations in common, and so developers can describe a table that is coming.
Activity Guidelines for Alzheimer's Patients
Activities Guide for Patients with Alzheimer's
Better to pass the days of Alzheimer's patients, especially the proposed activities to ensure the quality of life have to rise?
A person with dementia can still likes and has some of the events. It must determine for each patient personally. To find appropriate activities and skills for the changing moods of the patients in the glory to be creative and flexible. Encouraging the patient to the activities, results should be considered, regardless of the execution, they failed to react gösterilmemeli patients. In early times easier to give patients recommendations. In later periods, may need more encouragement and help, you must be patient and stick to it. The patient showed some behavioral signs of distress and can result from being empty. The patient may be busy, happy to spend the day can be achieved more efficiently and behavioral symptoms that may be reduced or disappear. Daily activities that also protect the patient's remaining skills, their confidence duymalarına, they are more interested in can help. In addition, relatives of patients to communicate with the patient, contribute to rapprochement.
Suggestions are Is there a particular event? Simple activities often are better, especially dementia ağırlaştıkça table. Try to find activities of interest to the patient. Avoid, however challenging and complicated striving. Short-lived events, usually shorter than the duration of the patients to concentrate better. Sakala, create the opportunity to laugh together. Some patients, reading, playing musical instruments, such as wood sewing jobs or activities previously yapakları fondly still can play, one needs a little is to be encouraged. Exercise every day to walk the recommended physical activities and accompanied by music. Listening to music, popular songs, especially the patient's years of youth, sickness sustained during the long period of time. The patient should be encouraged to accompany the songs. I often go out, sit in a park or garden tea is good for both patients and relatives, as well as a change of environment allows you to establish contact with other people. Most patients with dementia-tap okşayabilecekleri cats, pets such as dogs react positively. Soft toys can relax fondle them. Advanced stage patients increasingly difficult to co-operate. This type of massage in patients with and listen to soothing music may help.
Better to pass the days of Alzheimer's patients, especially the proposed activities to ensure the quality of life have to rise?
A person with dementia can still likes and has some of the events. It must determine for each patient personally. To find appropriate activities and skills for the changing moods of the patients in the glory to be creative and flexible. Encouraging the patient to the activities, results should be considered, regardless of the execution, they failed to react gösterilmemeli patients. In early times easier to give patients recommendations. In later periods, may need more encouragement and help, you must be patient and stick to it. The patient showed some behavioral signs of distress and can result from being empty. The patient may be busy, happy to spend the day can be achieved more efficiently and behavioral symptoms that may be reduced or disappear. Daily activities that also protect the patient's remaining skills, their confidence duymalarına, they are more interested in can help. In addition, relatives of patients to communicate with the patient, contribute to rapprochement.
Suggestions are Is there a particular event? Simple activities often are better, especially dementia ağırlaştıkça table. Try to find activities of interest to the patient. Avoid, however challenging and complicated striving. Short-lived events, usually shorter than the duration of the patients to concentrate better. Sakala, create the opportunity to laugh together. Some patients, reading, playing musical instruments, such as wood sewing jobs or activities previously yapakları fondly still can play, one needs a little is to be encouraged. Exercise every day to walk the recommended physical activities and accompanied by music. Listening to music, popular songs, especially the patient's years of youth, sickness sustained during the long period of time. The patient should be encouraged to accompany the songs. I often go out, sit in a park or garden tea is good for both patients and relatives, as well as a change of environment allows you to establish contact with other people. Most patients with dementia-tap okşayabilecekleri cats, pets such as dogs react positively. Soft toys can relax fondle them. Advanced stage patients increasingly difficult to co-operate. This type of massage in patients with and listen to soothing music may help.
Alzheimer's Patients Day Nursery, Alzheimer's Foundation
A world-renowned expert on Alzheimer's. Alzheimer's Association have set up in Turkey. Alzheimer's society in relation to the need to navigate to the correct address. In this context, what would you say?
Alzheimer's Association, founded in 1997 in Turkey. From its inception, the number one objective was to highlight that it is a disease. His slogan for the Alzheimer's Association is a self-made: "Dementia, is not a natural consequence of aging. Dementia, old age is not destiny." This slogan aimed to raise community awareness of the disease and also provided a great extent. However, Alzheimer's and other dementia patients and their relatives as much as possible we aim to provide a better quality of life. Provide medical and financial support as an association is not possible in all patients. The first thing we want to do, to inform relatives of patients. For this purpose, brochures, books, booklets have removed. From time to time patients' relatives seminars, training, maintenance courses are organized. In addition, patients family support "group call, the event was very useful: the ten-fifteen patients' relatives are coming together, talking to each other under the supervision of a qualified psychologist, problems, find solutions and share their troubles.
Where have branch offices? Alzheimer's Care
Centre in Istanbul. To date, Bursa, Izmir, Ankara, Adana, Denizli, Eskişehir and opened branch offices. Stage of setting up branch offices in Mersin and Samsun. Some branches, for example, Denizli, almost from the start, a large number of patients out into association studies is very useful and successful work they did. Eskisehir branch with the help of the mayor, began providing service to convert an apartment into a nursing home during the day. Ankara branch office in cooperation with the Regional Directorate of Social Services launched a day care center. Alzheimer's Foundation, established in 2000 three years after the establishment of the association. Alzheimer's Foundation Alzheimer's Association, and the two organizations work hand in hand. Alzheimer's Foundation, providing support to the Central branch Koşuyolu'nda Bakımevi'nin helped to open Turkey's first Alzheimer's Disease.
Our own building in the coming years, primarily to establish a permanent nursing home. Cheers for a bağışçımız promised, together determine the location. In addition, both the local authorities, in cooperation with state institutions as well as day care centers would like to propagate. Relatives of the patients in our culture because their patients are afraid to leave a permanent care centers. This is behind the 'cismen, "Do you blame me, his mother or his father threw the beginning of aging, nursing home, sent a wonder they say" have to worry about. However, nursing home quality of life of patients remaining at home often can be better bakılanlardan. Still, concern that such a built-in day care for sick relatives to look hot. Not enough for him everywhere in Turkey necessary to open a nursing home during the day.
Alzheimer's Association, founded in 1997 in Turkey. From its inception, the number one objective was to highlight that it is a disease. His slogan for the Alzheimer's Association is a self-made: "Dementia, is not a natural consequence of aging. Dementia, old age is not destiny." This slogan aimed to raise community awareness of the disease and also provided a great extent. However, Alzheimer's and other dementia patients and their relatives as much as possible we aim to provide a better quality of life. Provide medical and financial support as an association is not possible in all patients. The first thing we want to do, to inform relatives of patients. For this purpose, brochures, books, booklets have removed. From time to time patients' relatives seminars, training, maintenance courses are organized. In addition, patients family support "group call, the event was very useful: the ten-fifteen patients' relatives are coming together, talking to each other under the supervision of a qualified psychologist, problems, find solutions and share their troubles.
Where have branch offices? Alzheimer's Care
Centre in Istanbul. To date, Bursa, Izmir, Ankara, Adana, Denizli, Eskişehir and opened branch offices. Stage of setting up branch offices in Mersin and Samsun. Some branches, for example, Denizli, almost from the start, a large number of patients out into association studies is very useful and successful work they did. Eskisehir branch with the help of the mayor, began providing service to convert an apartment into a nursing home during the day. Ankara branch office in cooperation with the Regional Directorate of Social Services launched a day care center. Alzheimer's Foundation, established in 2000 three years after the establishment of the association. Alzheimer's Foundation Alzheimer's Association, and the two organizations work hand in hand. Alzheimer's Foundation, providing support to the Central branch Koşuyolu'nda Bakımevi'nin helped to open Turkey's first Alzheimer's Disease.
Our own building in the coming years, primarily to establish a permanent nursing home. Cheers for a bağışçımız promised, together determine the location. In addition, both the local authorities, in cooperation with state institutions as well as day care centers would like to propagate. Relatives of the patients in our culture because their patients are afraid to leave a permanent care centers. This is behind the 'cismen, "Do you blame me, his mother or his father threw the beginning of aging, nursing home, sent a wonder they say" have to worry about. However, nursing home quality of life of patients remaining at home often can be better bakılanlardan. Still, concern that such a built-in day care for sick relatives to look hot. Not enough for him everywhere in Turkey necessary to open a nursing home during the day.
Alzheimer's Treatment
Treatment of Alzheimer's Disease; Medicated treatment
What durumdayız the treatment of Alzheimer's disease? Pick from the same family or with Alzheimer's disease and DLB (diffuse Lewy body dementia) diseases, such as a treatment method to stop or turn back, not yet. We have drugs that can eliminate the symptoms of partial extent. We collect the treatment under two headings: non-drug therapy and drug therapy. Drug treatment also dedicating two. Disease-specific and non-specific treatments. Besides the loss of brain cells of Alzheimer's patients, some chemical substances needed for normal functioning of the brain azalıyorlar. These brain cells use to communicate with each other substances, carrying a kind of message from a cell to the other. One of these substances acetylcholine. Acetylcholine, an important matter for attention and memory functions. Alzheimer's disease brain, acetylcholine serious amounts of material is reduced. The first group of drugs currently used in the treatment of Alzheimer's disease brain acetylcholine miktannı raising the original. You carry out the brain by blocking the destruction of existing asetilkolin'in. This group is currently in use, the 3 active ingredient drug available (donepezil, rivastigmine, Gala-vitamin). This is a partial improvement in terms of symptoms with drugs or being stabilized, we see a partial slowdown. A second group of drugs, brain cells use to communicate with each other via a substance called glutamate in the brains of patients with Alzheimer's has effect in this system have a disorder. In this group, we now have a single drug (memantine). This drug provides glutamatergic system function more effectively. These two groups on drug treatment for the disease constitute a single original.
What treatments are not the original? Alzheimer's Treatment
These are non-specific drugs for this disease has a direct. This type of drugs we use in other diseases. For example, in patients with schizophrenia use drugs, dreams, delusions suppresses, aggression, and sometimes it works to treat sleep disorders. Depression is a problem frequently seen in Alzheimer's patients. Drugs used in patients with depression, Alzheimer's disease or use. Patient to a quieter, more compliant, to make less tense. Delusions, hırçınlıklar, dreams, sleep disorders, behavioral symptoms such as restlessness, sometimes for the family may become even more important. Relatives of the patient, sometimes they will say, "Doctor Bey, yes the memory was bad, remember, was addicted to him, but now these dreams, do not have these accusations, we are miserable. Working Woman accuses, blames me, constantly kovuyor bakıcısını. Giderebilirsek them, we razıyız amnesia ". We have drugs that reduce symptoms in most patients it is possible.
In general, more difficult to resolve the symptoms of this disease due to loss of direct cell. For example, memory disturbance, not cells are no longer required to record new events, save memories. Or because they can not keep the urine of bladder control is necessary for the cells no longer exists. However, the symptoms arising from the elimination of the remaining cells is usually easier to work incorrectly. For example, dreams, delusions harmonious working between the deterioration of the remaining cells being born. Intervention may be easier to suppress them, because here, at least the existing cells.
To sum up the moment we have not even durduramasak disease treatment methods, usually the patient and their relatives are able to offer a bit of a better life.
Non-drug treatment: Treatment of Alzheimer's patients inatlaşmamak
Also mentioned that non-drug approaches.
Yes, next to non-drug approaches to drug treatment is important to us. In this context, the most important first step is to accept that it is a disease. One of the great injustice done to patients due to an illness symptoms that patients do not accept the blame. "Getting older, was stubborn, was obsessed with her for doing it, so that people forget that, I guess is to draw attention to the" I think. Alzheimer's disease, a brain disease that is completely organic origin. You need to make no never mind.
Alzheimer's patients should be how the right approach?
Really very important to know how to treat patients with the patients' relatives. Hırçınlığın correct approaches often, it may be possible to prevent unrest and drug use for this purpose does not need to. Here zıtlaşmamak patient, there are some general principles such as inatlaşmamak. For example, the patient, usually late afternoon and says, "This is not my home, I'll go to my house, dinner was waiting for my mother." Correct form of behavior, "That's right, your mother is waiting, you should go home. Let's take you home" means. An attitude of supporting the patient in question, because here hezeyanını. This drawback, the patient suddenly, "But my mother was dying, even at the funeral did you you, you're lying to me," you say, and lose confidence. The second error is to do, "Are you crazy? Mother had been dead for thirty years. In this house we are sitting together with twenty-five years. Sit down, instead of saying" confrontation. The most healthy form of approach, before the patient to return to work in a quiet way to reality, this does not work in another direction as far as possible draw attention to the patient or to offer another option that can be accepted. For example, the "Look, this is your house. In fact, it was also you. Do not you remember" to try the style, or at least, "Perhaps now you 're confused, come back after getting a drink before you want to talk" approach, trying to avoid zıtlaşmaktan. Eşyasının persistently claimed was stolen from a patient, "Maybe somewhere koymuşsundur, you want to look at together as" close.
Memory, "pickle jar" for example
Another important approach, time and events often remind the patient. For example, looking at the newspaper, a well-known person, for example, Suleyman Demirel, a picture show, "Do you remember the previous cumhurbaşkanıydı, remember Ozal was late. You made the following such as". There is a very typical feature of Alzheimer's patients with memory disorders. Memory loss, deletion of the closest events begins. Often past events, far better protected in the past. For example, the patient does not remember what happened yesterday, but I can remember what happened ten years ago, or even begin to remember childhood better. We are sick relatives, "pickle jar" We give the example. Imagine you put cube cucumber pickles. Top first put cucumbers, cucumbers put in the bottom of the last receive. Memory impairment in Alzheimer's patients have such a feature. Saved on the most recent first are lost, are lost to memory as the most recent first konanlar.
Do you think all these measures, an increase of Alzheimer's patients quality of life do you have?
Our main goal is to raise as much as possible quality of life of patients and their relatives. Drug therapy is the primary aim of keeping the patient as possible where it is. Alzheimer's disease drugs, which spoke of the original. The difference of about 20 percent of patients with drugs that can be available to us, but it provided a temporary improvement. Where it is possible to keep about 60 percent of the patients in this period, there may be a year or three years. While 20 percent of patients, drugs are useless as it seems. Current drug therapy should not expect miraculous results. Alzheimer's disease is a progressive disease, approximately 7-8 years to change from one patient throughout the growing signs of a disease. Yavaşlatabilirsek how much progress we think we are so useful.
The rate of progression of the disease and what determines it to be variable from person to person?
Person's genetic structure, characteristics of the brain, to some extent looking at how well the family or looking after the environment conditions. Ultimately, however, all Alzheimer's ill enough long we live, because of another disease kaybedilmezlerse, become full of disrepair.
In this way, comparable to Alzheimer's disease, a neurological Is there another?
In the course of diseases like Alzheimer's dementia, a relative of the other. Pick disease is like that, DLB (diffuse Lewy body dementia) is one such patient. In other words, the brain degenerative diseases that cause dementia end point of a patient in need of care is always right.
That is like a baby. Already, "The baby was like," it said among the people. Behold how a baby is born exactly in need of help ...
Yes it is. Another point to be emphasized is this: if a sudden change in Alzheimer's patients always have to look for a different reason below. Let's say that the way to the patient stable or rapidly broke down suddenly, within a few days seriously deteriorated. Always have to look for a different reason below. Alzheimer's disease in elderly people in general, all other diseases of old age they may also occur. These patients often develop infections. urinary infection, lung infection, influenza, such as colds. These patients are aware of their problems or complaints varamazlar may not describe. Another common problem is that the water loss. The patient is left on its own might not be liquid enough or good enough not feed. In such a patient, for example a hot summer day, water loss may deteriorate rapidly and serious.
Death can take it?
Yes, even lead to death. Typically, patients' relatives say, "Doctor Bey, who seemed to know, was going well, but the last two-three days, head is too confused. Now you know where you are, not allowing me started. Two-three days before was not the case." Here's another reason underlying such a situation necessarily have to look for. Infections other than water loss and sometimes unconsciously on the advice received from the drugs may cause sudden deterioration.
Elderly depression
One of the reasons this may have depression? Depression does not make a sudden deterioration, but depression in old age would be appropriate to open a separate item. Because depression is a complex and intertwined relationship between dementia. First, serious depression, dementia can make a table. A person with severe depression, mental functions deteriorate so much as that of a clinical dementia in this, but it can be treated, a dementia dönülebilen back. Whether successful treatment of depression tamamlayabilirseniz, dementia in table are eliminated. The second point in the relationship between depression and dementia in the following: forgetfulness typically begins with symptoms of depression, although sometimes start with Alzheimer's disease. For the patient, "was pessimistic, was taken into the, now does not enjoy life, no energy, frequent crying, does not do anything inside," as reported complaints. In fact, a survey has been made in Sweden. In his youth not had any depression, the first old age starting to show signs of depression, especially depression and approximately 50 percent of patients do not respond to drugs within 5 years, this study shows that have developed Alzheimer's disease. Dementia-depression relationship, the third point is the following: Alzheimer's disease itself, may show symptoms of depression during the course. Mental loss of the patient, for example, aware of memory deterioration independent enterprises, then allowed to depression. Or as a completely organic, ie, Alzheimer's disease, the symptoms of depression may occur due to deterioration caused by brain chemistry.
Depression is often seen in old age? Depression is very common in the elderly. Elderly; spouse loss, loss of business, environmental loss, the loss of friends as a result of becoming more prone to depression, social isolation, and brought it. But depression is not only the problem of old age. In fact, he'll tell us, "I've been forgetful, I wonder bunuyor Am" I find depression in 90 percent of the young or middle aged people. As I mentioned before, because of depression, mental slowing functions, alertness, concentration, speed of mental operation disrupts the situation. Therefore, young or old, a table similar to depression, dementia may occur in every person entering.
Run your head, Alzheimer's disease protected
What are the risk factors for Alzheimer's disease and Alzheimer's disease by preventing possible? Age the risk of Alzheimer's disease is a known number. As people age, increasing the risk of Alzheimer's disease. Among the other known risks have already been severe head trauma. Increasingly we understand better what we call vascular risk factors, high blood pressure, diabetes, blood pressure values, especially middle-aged, middle age, cholesterol level, determining the risk of Alzheimer's disease. If the blood pressure or high cholesterol increases the risk of disease. "Is it possible to prevent Alzheimer's disease," he answered without hesitation when asked provide:
"Uygulayacağınız general principle is this: every thing is good for your heart is also good for your brain. In other words, reduce high blood pressure, reduce high cholesterol, if you have to treat diabetes, overweight reduce your weight, saturated fats, animal fats to avoid, how to implement adequate and balanced diet. I need to consume enough fresh fruits and vegetables. " When you make them, the risk of Alzheimer's disease, but relatively inmiyor reduced to zero. There is another interesting observation: using your brain working in the forefront of his business, the risk of Alzheimer's disease in humans, at least when compared to using her body. In other words, to use his brain to some extent protects against Alzheimer's disease. Another interesting observation in humans of the highly educated, less risk of Alzheimer's disease. Shows, however, emerged when a more rapid course.
Why is this happening?
The reason is unknown. Less common than high-educated people have opinions on the two: one, it is entirely in the direction of an illusion. The second opinion is as follows: The higher a person's mental capacity, how much and how many cells from the cell connection is doing is keeping active, even if these losses is a critical amount of the remaining cells are less likely to fall below the threshold. Brain cells, say, fifty billion there, and it should work at least forty billion. The fifty billion cells that make lots of connections between them and keeps them all active in humans, are more likely to fall below a certain threshold of capacity is small. For her mental reserve, maintain a high mental capacity, a great advantage to keep alive.
How do I need to run it?
There is only one method. For instance, my patients or their relatives are asking: "Puzzle çözeyim?" Yes, this is a method. Puzzle you can solve, but to do composition may be in a different way, could write a book, his friends may enter the intellectual debate. The important thing is make a mental activity.
50 percent of depressed patients' relatives
Did bracketing possible to give a number for our society?
Ideally, every neighborhood should be. And day care centers have to be especially large districts in each. Think of the elderly day care and day care centers, you know, working parents leave their children take morning and evening are taking. Day nursery to serve such a purpose. Everyone has the natural needs. Have to go shopping, have to take money from the bank, nothing if not one day have to take a breath. If the patient brings the family once a week, morning afternoon taking leave, the power at that time doing his job, relax psychologically. Relatives of patients in the treatment of Alzheimer's patients have an important place. He should also be healthy. Not very different from any other disease in patients with Alzheimer's only affects the family closely. In fact, there is a phrase used by Alzheimer's experts: "In the beginning there is a patient, time is of the patient," he. Because 50 percent of the relatives of Alzheimer's patients show symptoms of depression.
Then when treating patients with Alzheimer's, also close to the patient should not be overlooked.
Exactly. Both the patient and the health of that person's health, time of entry into depression because relatives are more impatient, more quickly sinirlenebiliyor, kırabiliyor patients. After that, he begins remorse, "Well, I had to not say, why say" he. And so begins a vicious cycle. Remorse, more emotional burden, the more depressive tendency, as a result of being frustrated people are starting to become a vicious cycle. Alzheimer's experts, for him, the patient controls the mental status of patients' relatives during the interrogations advised.
Alzheimer's disease, psychological, social and community where You put in?
The economic burden of this disease, both in terms of society, as well as socio-economic dimension of work, frequency, aging populations increasingly important in terms of the truth will emerge even more frequently. If the size of the affected person and their family different from other diseases, because the patient is changing, remove that person from being a person makes to another: People, who himself habits, character, begins to destroy the memories. For him, there is a heavy psychological burden of disease for patients and their relatives.
But despite all this, to be relatives of Alzheimer's disease or not sayılmamalı end of the world?
It is. Because the other people trying to help professionals work together to raise both the quality of life of patients and the patients' relatives, trying to share the burden. Relative of the patient as a person to feel helpless, panic kapılması, because of the possibilities the future has already started to worry would be a mistake. Problems occur when one has the solutions. Relatives of patients with Alzheimer's for her I say: "First, so let's try to solve the current problems. You try to upgrade the quality of the patient's life. In time, other problems occur, then try to find the necessary solutions."
What durumdayız the treatment of Alzheimer's disease? Pick from the same family or with Alzheimer's disease and DLB (diffuse Lewy body dementia) diseases, such as a treatment method to stop or turn back, not yet. We have drugs that can eliminate the symptoms of partial extent. We collect the treatment under two headings: non-drug therapy and drug therapy. Drug treatment also dedicating two. Disease-specific and non-specific treatments. Besides the loss of brain cells of Alzheimer's patients, some chemical substances needed for normal functioning of the brain azalıyorlar. These brain cells use to communicate with each other substances, carrying a kind of message from a cell to the other. One of these substances acetylcholine. Acetylcholine, an important matter for attention and memory functions. Alzheimer's disease brain, acetylcholine serious amounts of material is reduced. The first group of drugs currently used in the treatment of Alzheimer's disease brain acetylcholine miktannı raising the original. You carry out the brain by blocking the destruction of existing asetilkolin'in. This group is currently in use, the 3 active ingredient drug available (donepezil, rivastigmine, Gala-vitamin). This is a partial improvement in terms of symptoms with drugs or being stabilized, we see a partial slowdown. A second group of drugs, brain cells use to communicate with each other via a substance called glutamate in the brains of patients with Alzheimer's has effect in this system have a disorder. In this group, we now have a single drug (memantine). This drug provides glutamatergic system function more effectively. These two groups on drug treatment for the disease constitute a single original.
What treatments are not the original? Alzheimer's Treatment
These are non-specific drugs for this disease has a direct. This type of drugs we use in other diseases. For example, in patients with schizophrenia use drugs, dreams, delusions suppresses, aggression, and sometimes it works to treat sleep disorders. Depression is a problem frequently seen in Alzheimer's patients. Drugs used in patients with depression, Alzheimer's disease or use. Patient to a quieter, more compliant, to make less tense. Delusions, hırçınlıklar, dreams, sleep disorders, behavioral symptoms such as restlessness, sometimes for the family may become even more important. Relatives of the patient, sometimes they will say, "Doctor Bey, yes the memory was bad, remember, was addicted to him, but now these dreams, do not have these accusations, we are miserable. Working Woman accuses, blames me, constantly kovuyor bakıcısını. Giderebilirsek them, we razıyız amnesia ". We have drugs that reduce symptoms in most patients it is possible.
In general, more difficult to resolve the symptoms of this disease due to loss of direct cell. For example, memory disturbance, not cells are no longer required to record new events, save memories. Or because they can not keep the urine of bladder control is necessary for the cells no longer exists. However, the symptoms arising from the elimination of the remaining cells is usually easier to work incorrectly. For example, dreams, delusions harmonious working between the deterioration of the remaining cells being born. Intervention may be easier to suppress them, because here, at least the existing cells.
To sum up the moment we have not even durduramasak disease treatment methods, usually the patient and their relatives are able to offer a bit of a better life.
Non-drug treatment: Treatment of Alzheimer's patients inatlaşmamak
Also mentioned that non-drug approaches.
Yes, next to non-drug approaches to drug treatment is important to us. In this context, the most important first step is to accept that it is a disease. One of the great injustice done to patients due to an illness symptoms that patients do not accept the blame. "Getting older, was stubborn, was obsessed with her for doing it, so that people forget that, I guess is to draw attention to the" I think. Alzheimer's disease, a brain disease that is completely organic origin. You need to make no never mind.
Alzheimer's patients should be how the right approach?
Really very important to know how to treat patients with the patients' relatives. Hırçınlığın correct approaches often, it may be possible to prevent unrest and drug use for this purpose does not need to. Here zıtlaşmamak patient, there are some general principles such as inatlaşmamak. For example, the patient, usually late afternoon and says, "This is not my home, I'll go to my house, dinner was waiting for my mother." Correct form of behavior, "That's right, your mother is waiting, you should go home. Let's take you home" means. An attitude of supporting the patient in question, because here hezeyanını. This drawback, the patient suddenly, "But my mother was dying, even at the funeral did you you, you're lying to me," you say, and lose confidence. The second error is to do, "Are you crazy? Mother had been dead for thirty years. In this house we are sitting together with twenty-five years. Sit down, instead of saying" confrontation. The most healthy form of approach, before the patient to return to work in a quiet way to reality, this does not work in another direction as far as possible draw attention to the patient or to offer another option that can be accepted. For example, the "Look, this is your house. In fact, it was also you. Do not you remember" to try the style, or at least, "Perhaps now you 're confused, come back after getting a drink before you want to talk" approach, trying to avoid zıtlaşmaktan. Eşyasının persistently claimed was stolen from a patient, "Maybe somewhere koymuşsundur, you want to look at together as" close.
Memory, "pickle jar" for example
Another important approach, time and events often remind the patient. For example, looking at the newspaper, a well-known person, for example, Suleyman Demirel, a picture show, "Do you remember the previous cumhurbaşkanıydı, remember Ozal was late. You made the following such as". There is a very typical feature of Alzheimer's patients with memory disorders. Memory loss, deletion of the closest events begins. Often past events, far better protected in the past. For example, the patient does not remember what happened yesterday, but I can remember what happened ten years ago, or even begin to remember childhood better. We are sick relatives, "pickle jar" We give the example. Imagine you put cube cucumber pickles. Top first put cucumbers, cucumbers put in the bottom of the last receive. Memory impairment in Alzheimer's patients have such a feature. Saved on the most recent first are lost, are lost to memory as the most recent first konanlar.
Do you think all these measures, an increase of Alzheimer's patients quality of life do you have?
Our main goal is to raise as much as possible quality of life of patients and their relatives. Drug therapy is the primary aim of keeping the patient as possible where it is. Alzheimer's disease drugs, which spoke of the original. The difference of about 20 percent of patients with drugs that can be available to us, but it provided a temporary improvement. Where it is possible to keep about 60 percent of the patients in this period, there may be a year or three years. While 20 percent of patients, drugs are useless as it seems. Current drug therapy should not expect miraculous results. Alzheimer's disease is a progressive disease, approximately 7-8 years to change from one patient throughout the growing signs of a disease. Yavaşlatabilirsek how much progress we think we are so useful.
The rate of progression of the disease and what determines it to be variable from person to person?
Person's genetic structure, characteristics of the brain, to some extent looking at how well the family or looking after the environment conditions. Ultimately, however, all Alzheimer's ill enough long we live, because of another disease kaybedilmezlerse, become full of disrepair.
In this way, comparable to Alzheimer's disease, a neurological Is there another?
In the course of diseases like Alzheimer's dementia, a relative of the other. Pick disease is like that, DLB (diffuse Lewy body dementia) is one such patient. In other words, the brain degenerative diseases that cause dementia end point of a patient in need of care is always right.
That is like a baby. Already, "The baby was like," it said among the people. Behold how a baby is born exactly in need of help ...
Yes it is. Another point to be emphasized is this: if a sudden change in Alzheimer's patients always have to look for a different reason below. Let's say that the way to the patient stable or rapidly broke down suddenly, within a few days seriously deteriorated. Always have to look for a different reason below. Alzheimer's disease in elderly people in general, all other diseases of old age they may also occur. These patients often develop infections. urinary infection, lung infection, influenza, such as colds. These patients are aware of their problems or complaints varamazlar may not describe. Another common problem is that the water loss. The patient is left on its own might not be liquid enough or good enough not feed. In such a patient, for example a hot summer day, water loss may deteriorate rapidly and serious.
Death can take it?
Yes, even lead to death. Typically, patients' relatives say, "Doctor Bey, who seemed to know, was going well, but the last two-three days, head is too confused. Now you know where you are, not allowing me started. Two-three days before was not the case." Here's another reason underlying such a situation necessarily have to look for. Infections other than water loss and sometimes unconsciously on the advice received from the drugs may cause sudden deterioration.
Elderly depression
One of the reasons this may have depression? Depression does not make a sudden deterioration, but depression in old age would be appropriate to open a separate item. Because depression is a complex and intertwined relationship between dementia. First, serious depression, dementia can make a table. A person with severe depression, mental functions deteriorate so much as that of a clinical dementia in this, but it can be treated, a dementia dönülebilen back. Whether successful treatment of depression tamamlayabilirseniz, dementia in table are eliminated. The second point in the relationship between depression and dementia in the following: forgetfulness typically begins with symptoms of depression, although sometimes start with Alzheimer's disease. For the patient, "was pessimistic, was taken into the, now does not enjoy life, no energy, frequent crying, does not do anything inside," as reported complaints. In fact, a survey has been made in Sweden. In his youth not had any depression, the first old age starting to show signs of depression, especially depression and approximately 50 percent of patients do not respond to drugs within 5 years, this study shows that have developed Alzheimer's disease. Dementia-depression relationship, the third point is the following: Alzheimer's disease itself, may show symptoms of depression during the course. Mental loss of the patient, for example, aware of memory deterioration independent enterprises, then allowed to depression. Or as a completely organic, ie, Alzheimer's disease, the symptoms of depression may occur due to deterioration caused by brain chemistry.
Depression is often seen in old age? Depression is very common in the elderly. Elderly; spouse loss, loss of business, environmental loss, the loss of friends as a result of becoming more prone to depression, social isolation, and brought it. But depression is not only the problem of old age. In fact, he'll tell us, "I've been forgetful, I wonder bunuyor Am" I find depression in 90 percent of the young or middle aged people. As I mentioned before, because of depression, mental slowing functions, alertness, concentration, speed of mental operation disrupts the situation. Therefore, young or old, a table similar to depression, dementia may occur in every person entering.
Run your head, Alzheimer's disease protected
What are the risk factors for Alzheimer's disease and Alzheimer's disease by preventing possible? Age the risk of Alzheimer's disease is a known number. As people age, increasing the risk of Alzheimer's disease. Among the other known risks have already been severe head trauma. Increasingly we understand better what we call vascular risk factors, high blood pressure, diabetes, blood pressure values, especially middle-aged, middle age, cholesterol level, determining the risk of Alzheimer's disease. If the blood pressure or high cholesterol increases the risk of disease. "Is it possible to prevent Alzheimer's disease," he answered without hesitation when asked provide:
"Uygulayacağınız general principle is this: every thing is good for your heart is also good for your brain. In other words, reduce high blood pressure, reduce high cholesterol, if you have to treat diabetes, overweight reduce your weight, saturated fats, animal fats to avoid, how to implement adequate and balanced diet. I need to consume enough fresh fruits and vegetables. " When you make them, the risk of Alzheimer's disease, but relatively inmiyor reduced to zero. There is another interesting observation: using your brain working in the forefront of his business, the risk of Alzheimer's disease in humans, at least when compared to using her body. In other words, to use his brain to some extent protects against Alzheimer's disease. Another interesting observation in humans of the highly educated, less risk of Alzheimer's disease. Shows, however, emerged when a more rapid course.
Why is this happening?
The reason is unknown. Less common than high-educated people have opinions on the two: one, it is entirely in the direction of an illusion. The second opinion is as follows: The higher a person's mental capacity, how much and how many cells from the cell connection is doing is keeping active, even if these losses is a critical amount of the remaining cells are less likely to fall below the threshold. Brain cells, say, fifty billion there, and it should work at least forty billion. The fifty billion cells that make lots of connections between them and keeps them all active in humans, are more likely to fall below a certain threshold of capacity is small. For her mental reserve, maintain a high mental capacity, a great advantage to keep alive.
How do I need to run it?
There is only one method. For instance, my patients or their relatives are asking: "Puzzle çözeyim?" Yes, this is a method. Puzzle you can solve, but to do composition may be in a different way, could write a book, his friends may enter the intellectual debate. The important thing is make a mental activity.
50 percent of depressed patients' relatives
Did bracketing possible to give a number for our society?
Ideally, every neighborhood should be. And day care centers have to be especially large districts in each. Think of the elderly day care and day care centers, you know, working parents leave their children take morning and evening are taking. Day nursery to serve such a purpose. Everyone has the natural needs. Have to go shopping, have to take money from the bank, nothing if not one day have to take a breath. If the patient brings the family once a week, morning afternoon taking leave, the power at that time doing his job, relax psychologically. Relatives of patients in the treatment of Alzheimer's patients have an important place. He should also be healthy. Not very different from any other disease in patients with Alzheimer's only affects the family closely. In fact, there is a phrase used by Alzheimer's experts: "In the beginning there is a patient, time is of the patient," he. Because 50 percent of the relatives of Alzheimer's patients show symptoms of depression.
Then when treating patients with Alzheimer's, also close to the patient should not be overlooked.
Exactly. Both the patient and the health of that person's health, time of entry into depression because relatives are more impatient, more quickly sinirlenebiliyor, kırabiliyor patients. After that, he begins remorse, "Well, I had to not say, why say" he. And so begins a vicious cycle. Remorse, more emotional burden, the more depressive tendency, as a result of being frustrated people are starting to become a vicious cycle. Alzheimer's experts, for him, the patient controls the mental status of patients' relatives during the interrogations advised.
Alzheimer's disease, psychological, social and community where You put in?
The economic burden of this disease, both in terms of society, as well as socio-economic dimension of work, frequency, aging populations increasingly important in terms of the truth will emerge even more frequently. If the size of the affected person and their family different from other diseases, because the patient is changing, remove that person from being a person makes to another: People, who himself habits, character, begins to destroy the memories. For him, there is a heavy psychological burden of disease for patients and their relatives.
But despite all this, to be relatives of Alzheimer's disease or not sayılmamalı end of the world?
It is. Because the other people trying to help professionals work together to raise both the quality of life of patients and the patients' relatives, trying to share the burden. Relative of the patient as a person to feel helpless, panic kapılması, because of the possibilities the future has already started to worry would be a mistake. Problems occur when one has the solutions. Relatives of patients with Alzheimer's for her I say: "First, so let's try to solve the current problems. You try to upgrade the quality of the patient's life. In time, other problems occur, then try to find the necessary solutions."
Stages of Alzheimer's Disease
Stages of Alzheimer's Disease
Is the disease in the formation?
Yes, according to the first view, the main cause of the disease amyloid accumulation. Amyloid to accumulate in the cells die and begin to break the connections between cells. If the second opinion, tau protein accumulates in the cell claims to be the main culprit. According to this thesis, the tau protein accumulate in the cells died as a result, the cell, the cell starts to accumulate between the cells out of steel provides the answers reveal perindeki amyloid. Tau'cular In other words, "guilty of amyloid is not the result," they say, whereas the amyloid'ciler, "The real culprit amyloid'dir, it is the result of the accumulation of tau," they say.
What do you think?
When you look at the data we have is making all the genetic information amyloid'i guilty. Familial Alzheimer's disease-causing gene is detected that I had 3 pieces. All of these genes in the cell construction and destruction of genes involved in the amyloid protein. On the other hand there is the following observation: the brain of patients examined, with the accumulated amount of amyloid is no direct correlation between the severity of the patient's clinical symptoms. In fact, such extreme examples, however, some people throughout their lives, showed no signs of Alzheimer's, other reasons had passed away, the brains of amyloid has accumulated a significant amount of browsing.
Amyloid accumulates a certain amount of healthy aging brain of many people. When you look at the amount of tau protein accumulated in Tau'ya before the death of the patient can see a direct correlation between the severity of bunamasının. In short, the genetic findings suggest amyloid'ı, pathological findings and behold, tau'yu.
Alzheimer's disease is slowly progressing from an insidious way. The resulting symptoms
also can be different from period to period. Could you talk about the stages of the disease?
Stages of Alzheimer's disease is used to separate the different scales, for example, disease, 3, 5 or 7 has the stage that separates the scales. The simplest and easiest to understand what the early, middle and late phases, including ayıranı 3. This is roughly the following stages, the symptoms may arise as possible to sort:
Early stage: This period is usually overlooked by doctors and patients' relatives and wrongly perceived as a normal part of aging. Insidious onset of the disease when the first symptoms appeared to be difficult to determine clearly. The most significant finding in this period unutkanlıktır, as well as the difficulty of finding words in the patient, take time to be a trouble, especially to recognize familiar places and sometimes lost, take the initiative and may have trouble deciding. Quick temper, sudden glows, may show personality changes, such as social withdrawal. Begins to lose interest in hobbies and activities. Difficult to follow up a bank account and bills, and sometimes the money out of accounts of daily life is marked more than the selection of mixing or clothing there is a distortion.
Middle stage: As the disease progresses, symptoms may begin to affect more than evident, and daily life. The patient becomes increasingly forgetful, you can ask the same question over and over. Deletes events that happened recently never had ever existed. Güçleşmeye gradually starts to live alone without a problem. Salt changes the taste of food, burning of food sıklaşır. Starts to experience difficulties shopping. Bath, cleaning reminder, you may need in part to help. She spoke, stuttering, pauses can occur, begins with the difficulties in understanding complex sentences. If left on its own may be lost. Behavioral symptoms in the context of dreams, delusions, may occur inatlaşmayla acrimony.
Late Phase: During this period, the patient can not survive without assistance, is now completely ruined and backward memory impairment memory close to expand gradually, begin to cover the more distant past. Gradually the patient can not express himself well, never talk in recent times become longer, also does not understand what was said. Dressing, cleaning, going to eat you need full support. Now even recognize many relatives, urine and feces, and then keeping the problems begin to abductions. Patient care in recent decades is in need of a complete, speak, understand, usually quiet, where it was left sitting, walking slowed down or walk unaided, in the end, a bedridden patient.
Is the disease in the formation?
Yes, according to the first view, the main cause of the disease amyloid accumulation. Amyloid to accumulate in the cells die and begin to break the connections between cells. If the second opinion, tau protein accumulates in the cell claims to be the main culprit. According to this thesis, the tau protein accumulate in the cells died as a result, the cell, the cell starts to accumulate between the cells out of steel provides the answers reveal perindeki amyloid. Tau'cular In other words, "guilty of amyloid is not the result," they say, whereas the amyloid'ciler, "The real culprit amyloid'dir, it is the result of the accumulation of tau," they say.
What do you think?
When you look at the data we have is making all the genetic information amyloid'i guilty. Familial Alzheimer's disease-causing gene is detected that I had 3 pieces. All of these genes in the cell construction and destruction of genes involved in the amyloid protein. On the other hand there is the following observation: the brain of patients examined, with the accumulated amount of amyloid is no direct correlation between the severity of the patient's clinical symptoms. In fact, such extreme examples, however, some people throughout their lives, showed no signs of Alzheimer's, other reasons had passed away, the brains of amyloid has accumulated a significant amount of browsing.
Amyloid accumulates a certain amount of healthy aging brain of many people. When you look at the amount of tau protein accumulated in Tau'ya before the death of the patient can see a direct correlation between the severity of bunamasının. In short, the genetic findings suggest amyloid'ı, pathological findings and behold, tau'yu.
Alzheimer's disease is slowly progressing from an insidious way. The resulting symptoms
also can be different from period to period. Could you talk about the stages of the disease?
Stages of Alzheimer's disease is used to separate the different scales, for example, disease, 3, 5 or 7 has the stage that separates the scales. The simplest and easiest to understand what the early, middle and late phases, including ayıranı 3. This is roughly the following stages, the symptoms may arise as possible to sort:
Early stage: This period is usually overlooked by doctors and patients' relatives and wrongly perceived as a normal part of aging. Insidious onset of the disease when the first symptoms appeared to be difficult to determine clearly. The most significant finding in this period unutkanlıktır, as well as the difficulty of finding words in the patient, take time to be a trouble, especially to recognize familiar places and sometimes lost, take the initiative and may have trouble deciding. Quick temper, sudden glows, may show personality changes, such as social withdrawal. Begins to lose interest in hobbies and activities. Difficult to follow up a bank account and bills, and sometimes the money out of accounts of daily life is marked more than the selection of mixing or clothing there is a distortion.
Middle stage: As the disease progresses, symptoms may begin to affect more than evident, and daily life. The patient becomes increasingly forgetful, you can ask the same question over and over. Deletes events that happened recently never had ever existed. Güçleşmeye gradually starts to live alone without a problem. Salt changes the taste of food, burning of food sıklaşır. Starts to experience difficulties shopping. Bath, cleaning reminder, you may need in part to help. She spoke, stuttering, pauses can occur, begins with the difficulties in understanding complex sentences. If left on its own may be lost. Behavioral symptoms in the context of dreams, delusions, may occur inatlaşmayla acrimony.
Late Phase: During this period, the patient can not survive without assistance, is now completely ruined and backward memory impairment memory close to expand gradually, begin to cover the more distant past. Gradually the patient can not express himself well, never talk in recent times become longer, also does not understand what was said. Dressing, cleaning, going to eat you need full support. Now even recognize many relatives, urine and feces, and then keeping the problems begin to abductions. Patient care in recent decades is in need of a complete, speak, understand, usually quiet, where it was left sitting, walking slowed down or walk unaided, in the end, a bedridden patient.
Diseases causing dementia
Diseases causing dementia, Dementia Causes
Of selective cell death in brain diseases
Only dementia (dementia) diseases characterized by
Alzheimer's disease
Pick disease (frontotemporal dementia)
Slowly progressive language disorder (primary progressive aphasia)
Slowly progressive visual perception disorder (primary progressive agnosia)
Dementia is a neurological disease as well as other table
Widespread Lewy cisimcikti dementia (dementia with Lewy bodies, diffuse Levvy body disease)
Dementia due to Parkinson's disease
Huntington's disease
Progressive paralysis of eye movements (progressive supranuclear paresis)
Corticobasal ganglionic degeneration
Secondary dementias caused by
The reasons that creates a direct destruction of brain tissue
Vascular dementia as a result of clogging (vascular dementia)
Brain infection (microbial-inflammatory) as a result of dementia
Disrupts the hormonal balance of nutrition and diseases of the brain
Hormonal disorders: for example, the thyroid gland to work more or less
Metabolic disorders: eg, uremia (kidney failure)
Vitamin deficiencies: for example, a lack of vitamin B-12
Dementias caused by increased pressure within the head
Brain tumors
Increased pressure within the brain cavities (normal pressure hydrocephalus)
Accumulation of blood between the skull and the brain (subdural hematoma)
To be in the family, increases the risk 3-fold
I think one of the most asked questions is whether there is familial disease ...
Possible to examine the direction of familial Alzheimer's disease in two ways. First, the familial predisposition. This means: If a man in one of the first-degree relatives, mother, father, brother if you have Alzheimer's disease, Alzheimer's disease in that person's risk of developing the disease compared to those without family, growing up to 2-3 times. For example, a person from the age of 65 l. per cent risk of developing the disease. If the mother, father, first-degree relatives have Alzheimer's, this risk is around 2 to 3 percent. So this is a relative increase. When you look at the still low in absolute terms, but others have increased as compared to the relative. Familial predisposition to this call as the situation.
Second, a real sense, the "familial Alzheimer's disease," we say, the situation resulting from genetic disorders. To date, three different genes that cause familial Alzheimer's disease were identified, those that have not yet defined. Patients with this type of non-familial Alzheimer patients show slightly different symptoms: for example, usually begin at an earlier age, even beginners have 30s. Generally, are progressing more quickly and sometimes without the typical findings can occur.
What is the incidence of familial Alzheimer's disease?
Taken all Alzheimer's patients actually seen around 5 to 10 percent of familial Alzheimer's disease. In other words, every ten or twenty in one of the familial Alzheimer's patient in question.
Alzheimer's name come from, how this disease was discovered?
That identifies the name of this disease and other diseases, and pathologist Alois Alzheimer, a German neurologist. Dr. In 1906, followed by signs of Alzheimer's dementia patients died during 5-6 years after the "brain" of the brain, examines and describes the changes. Ill at the beginning of the age of 50s and 57-year-old female patient who had died in the name of Augusta D. Dr. Alois Alzheimer's, it examines the patient's brains, for the original, the classic symptoms of Alzheimer's disease is described clearly. Full hundred years ago, he hardly ever anything new on this recipe are not ekleyebilmiş. Previously, Alzheimer's disease is a rare disease, this disease is thought to occur at younger ages. Bunda Augusta D. 's being sick at a young age must have been effective. In the elderly with dementia, dementia is assumed that different. But in the last twenty years these two groups in both the clinical symptoms of the patient, as well as their brains were examined together, it seems there is no difference. The dementias are also very large part of the same age and Augusta D. 's brain, showing the changes. Alzheimer's disease is no longer called for it all and as this disease occurs more frequently in the elderly, the most common underlying cause appears to be dementia.
We could not find the trigger absorbed
Is known to cause Alzheimer's disease?
Durumdayız better understand Alzheimer's disease and crime scene so to speak, so we know quite well what was happening in the brain, but these changes do not yet know what started. In other words, crime is understood the place, but it attracted the trigger is unknown. Alzheimer's patients have a loss of brain cells in certain regions, the connections between cells that break. In addition, two very typical symptoms seen in the brains of patients: the first is deposited between the cells, we call on behalf of the amyloid protein is a qualified agent. This article, normally have cell walls. Alzheimer's disease is a part of this article are breaking loose, disconnected parts accumulate between the cells merge with each other, "record" is s. These "amyloid plaque" call. Second, the collapsing of a protein in the cells. The name of this protein, tau. Abnormal tau proteins in Alzheimer's disease with each other to set up links within the cells begin to crumble. At this point, two different hypotheses emerge.
Exceptions Benzeyebilen mistaken for dementia or dementia
Age-related mild forgetfulness
Mild cognitive impairment (mild cognitive impairment)
Depression or masked depression
Obsessed with psychiatric disorders, such as disease or old age psychosis
Physical illnesses or drug induced confusion, sudden onset (acute confusion)
Temporary general memory impairment (Transient global amnesia)
Of selective cell death in brain diseases
Only dementia (dementia) diseases characterized by
Alzheimer's disease
Pick disease (frontotemporal dementia)
Slowly progressive language disorder (primary progressive aphasia)
Slowly progressive visual perception disorder (primary progressive agnosia)
Dementia is a neurological disease as well as other table
Widespread Lewy cisimcikti dementia (dementia with Lewy bodies, diffuse Levvy body disease)
Dementia due to Parkinson's disease
Huntington's disease
Progressive paralysis of eye movements (progressive supranuclear paresis)
Corticobasal ganglionic degeneration
Secondary dementias caused by
The reasons that creates a direct destruction of brain tissue
Vascular dementia as a result of clogging (vascular dementia)
Brain infection (microbial-inflammatory) as a result of dementia
Disrupts the hormonal balance of nutrition and diseases of the brain
Hormonal disorders: for example, the thyroid gland to work more or less
Metabolic disorders: eg, uremia (kidney failure)
Vitamin deficiencies: for example, a lack of vitamin B-12
Dementias caused by increased pressure within the head
Brain tumors
Increased pressure within the brain cavities (normal pressure hydrocephalus)
Accumulation of blood between the skull and the brain (subdural hematoma)
To be in the family, increases the risk 3-fold
I think one of the most asked questions is whether there is familial disease ...
Possible to examine the direction of familial Alzheimer's disease in two ways. First, the familial predisposition. This means: If a man in one of the first-degree relatives, mother, father, brother if you have Alzheimer's disease, Alzheimer's disease in that person's risk of developing the disease compared to those without family, growing up to 2-3 times. For example, a person from the age of 65 l. per cent risk of developing the disease. If the mother, father, first-degree relatives have Alzheimer's, this risk is around 2 to 3 percent. So this is a relative increase. When you look at the still low in absolute terms, but others have increased as compared to the relative. Familial predisposition to this call as the situation.
Second, a real sense, the "familial Alzheimer's disease," we say, the situation resulting from genetic disorders. To date, three different genes that cause familial Alzheimer's disease were identified, those that have not yet defined. Patients with this type of non-familial Alzheimer patients show slightly different symptoms: for example, usually begin at an earlier age, even beginners have 30s. Generally, are progressing more quickly and sometimes without the typical findings can occur.
What is the incidence of familial Alzheimer's disease?
Taken all Alzheimer's patients actually seen around 5 to 10 percent of familial Alzheimer's disease. In other words, every ten or twenty in one of the familial Alzheimer's patient in question.
Alzheimer's name come from, how this disease was discovered?
That identifies the name of this disease and other diseases, and pathologist Alois Alzheimer, a German neurologist. Dr. In 1906, followed by signs of Alzheimer's dementia patients died during 5-6 years after the "brain" of the brain, examines and describes the changes. Ill at the beginning of the age of 50s and 57-year-old female patient who had died in the name of Augusta D. Dr. Alois Alzheimer's, it examines the patient's brains, for the original, the classic symptoms of Alzheimer's disease is described clearly. Full hundred years ago, he hardly ever anything new on this recipe are not ekleyebilmiş. Previously, Alzheimer's disease is a rare disease, this disease is thought to occur at younger ages. Bunda Augusta D. 's being sick at a young age must have been effective. In the elderly with dementia, dementia is assumed that different. But in the last twenty years these two groups in both the clinical symptoms of the patient, as well as their brains were examined together, it seems there is no difference. The dementias are also very large part of the same age and Augusta D. 's brain, showing the changes. Alzheimer's disease is no longer called for it all and as this disease occurs more frequently in the elderly, the most common underlying cause appears to be dementia.
We could not find the trigger absorbed
Is known to cause Alzheimer's disease?
Durumdayız better understand Alzheimer's disease and crime scene so to speak, so we know quite well what was happening in the brain, but these changes do not yet know what started. In other words, crime is understood the place, but it attracted the trigger is unknown. Alzheimer's patients have a loss of brain cells in certain regions, the connections between cells that break. In addition, two very typical symptoms seen in the brains of patients: the first is deposited between the cells, we call on behalf of the amyloid protein is a qualified agent. This article, normally have cell walls. Alzheimer's disease is a part of this article are breaking loose, disconnected parts accumulate between the cells merge with each other, "record" is s. These "amyloid plaque" call. Second, the collapsing of a protein in the cells. The name of this protein, tau. Abnormal tau proteins in Alzheimer's disease with each other to set up links within the cells begin to crumble. At this point, two different hypotheses emerge.
Exceptions Benzeyebilen mistaken for dementia or dementia
Age-related mild forgetfulness
Mild cognitive impairment (mild cognitive impairment)
Depression or masked depression
Obsessed with psychiatric disorders, such as disease or old age psychosis
Physical illnesses or drug induced confusion, sudden onset (acute confusion)
Temporary general memory impairment (Transient global amnesia)
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